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- W1981836706 abstract "In this article we provide an overview of the intersection between amyotrophic lateral sclerosis (ALS) and the autophagy pathway and discuss the potential protective effects of lithium through mechanisms that recruit autophagy and other effects. The autophagy pathway is recruited during motor neuron (MN) death both in vitro and in vivo. Despite a few controversial issues concerning the significance (detrimental/protective) of autophagy in ALS, recent findings indicate a protective role. Lithium in low doses is a well-known autophagy inducer that clears misfolded proteins and altered mitochondria from MNs. Moreover, lithium preserves mitochondria and sustains their genesis. This effect is replicated by rapamycin, which is an autophagy inducer but with a different mechanism from lithium. Lithium also increases the number of Renshaw cells that are affected early during the progression of experimental ALS. Again, lithium has been reported to decrease glial proliferation in the ALS spinal cord and induces sprouting in corticospinal fibers. Muscle Nerve 40: 173–194, 2009" @default.
- W1981836706 created "2016-06-24" @default.
- W1981836706 creator A5014588475 @default.
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- W1981836706 creator A5089036955 @default.
- W1981836706 creator A5090667408 @default.
- W1981836706 date "2009-07-16" @default.
- W1981836706 modified "2023-09-29" @default.
- W1981836706 title "Autophagy, lithium, and amyotrophic lateral sclerosis" @default.
- W1981836706 cites W141294482 @default.
- W1981836706 cites W1530114072 @default.
- W1981836706 cites W1543216066 @default.
- W1981836706 cites W1583737635 @default.
- W1981836706 cites W1589221989 @default.
- W1981836706 cites W179329376 @default.
- W1981836706 cites W1894493322 @default.
- W1981836706 cites W1963128268 @default.
- W1981836706 cites W1966587953 @default.
- W1981836706 cites W1966954417 @default.
- W1981836706 cites W1967066491 @default.
- W1981836706 cites W1968109664 @default.
- W1981836706 cites W1971397654 @default.
- W1981836706 cites W1971837252 @default.
- W1981836706 cites W1972177343 @default.
- W1981836706 cites W1972260106 @default.
- W1981836706 cites W1972618253 @default.
- W1981836706 cites W1972760525 @default.
- W1981836706 cites W1973610175 @default.
- W1981836706 cites W1977649097 @default.
- W1981836706 cites W1977767269 @default.
- W1981836706 cites W1979545106 @default.
- W1981836706 cites W1979591280 @default.
- W1981836706 cites W1979993283 @default.
- W1981836706 cites W1984869034 @default.
- W1981836706 cites W1984979116 @default.
- W1981836706 cites W1985917760 @default.
- W1981836706 cites W1986175588 @default.
- W1981836706 cites W1986242485 @default.
- W1981836706 cites W1986420650 @default.
- W1981836706 cites W1987522740 @default.
- W1981836706 cites W1991890632 @default.
- W1981836706 cites W1992051035 @default.
- W1981836706 cites W1997967702 @default.
- W1981836706 cites W1998521598 @default.
- W1981836706 cites W1999283564 @default.
- W1981836706 cites W1999638129 @default.
- W1981836706 cites W2000584920 @default.
- W1981836706 cites W2003643542 @default.
- W1981836706 cites W2004192426 @default.
- W1981836706 cites W2005235901 @default.
- W1981836706 cites W2006042612 @default.
- W1981836706 cites W2009473117 @default.
- W1981836706 cites W2010807883 @default.
- W1981836706 cites W2012846250 @default.
- W1981836706 cites W2013658320 @default.
- W1981836706 cites W2014386715 @default.
- W1981836706 cites W2015237292 @default.
- W1981836706 cites W2016794759 @default.
- W1981836706 cites W2018110972 @default.
- W1981836706 cites W2018447297 @default.
- W1981836706 cites W2018771027 @default.
- W1981836706 cites W2019031549 @default.
- W1981836706 cites W2019258749 @default.
- W1981836706 cites W2020059513 @default.
- W1981836706 cites W2020815630 @default.
- W1981836706 cites W2021148367 @default.
- W1981836706 cites W2022309233 @default.
- W1981836706 cites W2022812113 @default.
- W1981836706 cites W2024009556 @default.
- W1981836706 cites W2024153744 @default.
- W1981836706 cites W2024384866 @default.
- W1981836706 cites W2025364264 @default.
- W1981836706 cites W2026175550 @default.
- W1981836706 cites W2026411481 @default.
- W1981836706 cites W2029915133 @default.
- W1981836706 cites W2030627612 @default.
- W1981836706 cites W2032205778 @default.
- W1981836706 cites W2033052946 @default.
- W1981836706 cites W2033114420 @default.
- W1981836706 cites W2034703986 @default.
- W1981836706 cites W2034753731 @default.
- W1981836706 cites W2034766627 @default.
- W1981836706 cites W2034842853 @default.
- W1981836706 cites W2038049117 @default.
- W1981836706 cites W2038164359 @default.
- W1981836706 cites W2038697027 @default.
- W1981836706 cites W2040209654 @default.
- W1981836706 cites W2045160140 @default.
- W1981836706 cites W2046407150 @default.
- W1981836706 cites W2047304481 @default.
- W1981836706 cites W2047691740 @default.
- W1981836706 cites W2048788553 @default.
- W1981836706 cites W2049514362 @default.
- W1981836706 cites W2050340611 @default.
- W1981836706 cites W2052888134 @default.
- W1981836706 cites W2053088997 @default.