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- W1981837216 abstract "Infections by respiratory syncytial virus (RSV) are more severe in patients with cystic fibrosis (CF), and many CF units use palivizumab as prophylaxis; however, information about palivizumab efficacy in CF patients is almost lacking. A literature search up to December 2012 on the morbidity of RSV bronchiolitis in CF patients and on the safety and efficacy of palivizumab in those patients was performed. A random-effects meta-analysis was conducted for those studies meeting pre-specified search criteria. Historical controls were allowed. The number of patients who received palivizumab was 354 and the hospital admission rate was 0.018 (95% CI 0.0077–0.048). The corresponding number in the non-treated groups was 463 patients with an admission rate of 0.126 (95% CI 0.086–0.182) (Q = 13.9; p < 0.001). Palivizumab may have a role in the prevention of severe lower airway infection by RSV in CF patients." @default.
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- W1981837216 date "2015-05-01" @default.
- W1981837216 modified "2023-10-18" @default.
- W1981837216 title "Is palivizumab effective as a prophylaxis of respiratory syncytial virus infections in cystic fibrosis patients? A meta-analysis" @default.
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- W1981837216 doi "https://doi.org/10.1016/j.aller.2013.09.003" @default.
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