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- W1981840981 abstract "SummaryAmoxycillin is a new penicillin active against gram negative bacteria. Its antibacterial activity is similar to ampicillin and almost 90 % of the strains of Esch. coli and Proteus mirabilis studied were sensitive to 5 μg per ml. Strains of Klebsiella and other Proteus species were highly resistant.The peak serum level in volunteers after an oral dose of 500 mg. occurred at 2 hours and was 8.4 μg per ml. Urine levels were high and at 2 hours the concentration was nearly 2,000 μg per ml. The average total excretion was 67%.152 domiciliary patients with urinary tract infections were treated with amoxycillin and the cure rate two weeks after starting treatment was 92% and at six weeks 82 %. The presence of urinary tract abnormalities or a raised serum antibody titre against the infecting organisms significantly increased the failure rate.Side-effects were similar to other oral penicillins, mainly gastro-intestinal disturbances, vaginitis and skin rashes.Amoxycillin is a useful addition to the range of ..." @default.
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- W1981840981 date "1972-01-01" @default.
- W1981840981 modified "2023-10-17" @default.
- W1981840981 title "Diagnosis of urinary tract infections in general practice, and treatment with a new penicillin—amoxycillin" @default.
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- W1981840981 doi "https://doi.org/10.1185/03007997209111140" @default.
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