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• W1981845210 abstract "In this study we tested the hypothesis that extracellular ATP regulates the function of the pericyte-containing retinal microvessels. Pericytes, which are more numerous in the retina than in any other tissue, are abluminally located cells that may adjust capillary perfusion by contracting and relaxing. At present, knowledge of the vasoactive molecules that regulate pericyte function is limited. Here, we focused on the actions of extracellular ATP because this nucleotide is a putative glial-to-vascular signal, as well as being a substance released by activated platelets and injured cells. In microvessels freshly isolated from the adult rat retina, we monitored ionic currents via perforated-patch pipettes, measured intracellular calcium levels with the use of fura-2, and visualized microvascular contractions with the aid of time-lapse photography. We found that ATP induced depolarizing changes in the ionic currents, increased calcium levels and caused pericytes to contract. P2X7 receptors and UTP-activated receptors mediated these effects. Consistent with ATP serving as a vasoconstrictor for the pericyte-containing microvasculature of the retina, the microvascular lumen narrowed when an adjacent pericyte contracted. In addition, the sustained activation of P2X7 receptors inhibited cell-to-cell electrotonic transmission within the microvascular networks. Thus, ATP not only affects the contractility of individual pericytes, but also appears to regulate the spatial and temporal dynamics of the vasomotor response." @default.
• W1981845210 created "2016-06-24" @default.
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• W1981845210 date "2003-09-01" @default.
• W1981845210 modified "2023-10-11" @default.
• W1981845210 title "ATP: a vasoactive signal in the pericyte-containing microvasculature of the rat retina" @default.
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• W1981845210 doi "https://doi.org/10.1111/j.1469-7793.2003.00787.x" @default.
• W1981845210 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2343299" @default.
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