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- W1981876032 abstract "A 32-year-old woman who had taken oral contraceptives for seven years, became pregnant after omitting the drug and had a normal child. Soon after a malignant hepatic tumour became apparent of which she died after three months. The tumour was a hepatocellular carcinoma, of low differentiation under the electron microscope. The tumour cells contained fibrils similar to alcoholic hyaline. A review of published reports suggests the possibility that the oral contraceptives and the hormonal influence of the pregnancy together played an important role in the development of the malignant tumour.The case of a 32-year-old woman who, after 7 years of use of oral contraception, became pregnant, gave birth to a healthy child, and became afflicted with a malignant tumor is related. The tumor became apparent soon after the uncomplicated birth, its hepatic nature revealed through jaundice, and subsequent serological tests. The tumor was revealed to be a hepatocellular carcinoma of low differentiation under an electron microscope. The cancerous cells contained fibrils similar to alcoholic hyaline. Published reports suggest that there is a relation between the use of oral hormonal contraceptives and the hormonal changes the female organism goes through during pregnancy, which may be a causal factor in the appearance of carcinomas. The exact link between oral contraceptives and liver disruptions is not yet understood, although the effect upon the mitochondria and the endoplasmic reticula of the liver cells is thought to be important, particularly with anabolic steroids." @default.
- W1981876032 created "2016-06-24" @default.
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- W1981876032 date "1977-10-01" @default.
- W1981876032 modified "2023-09-25" @default.
- W1981876032 title "Primäres Leberkarzinom nach mehrjähriger Anwendung eines oralen Kontrazeptivums und Schwangerschaft" @default.
- W1981876032 doi "https://doi.org/10.1055/s-0028-1105524" @default.
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