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• W1981878280 abstract "In response to food reward and other pertinent events, midbrain dopaminergic neurons fire short bursts of action potentials causing a phasic release of dopamine in the prefrontal cortex (rapid and transient increases in cortical dopamine concentration). Here we apply short (2 s) iontophoretic pulses of glutamate, GABA, dopamine and dopaminergic agonists locally, onto layer 5 pyramidal neurons in brain slices of the rat medial prefrontal cortex (PFC). Unlike glutamate and GABA, brief dopaminergic pulses had negligible effects on the resting membrane potential. However, dopamine altered action potential firing in an extremely rapid (< 1 s) and transient (< 5 min) manner, as every neuron returned to baseline in less than 5-min post-application. The physiological responses to dopamine differed markedly among individual neurons. Pyramidal neurons with a preponderance of D1-like receptor signaling respond to dopamine with a severe depression in action potential firing rate, while pyramidal neurons dominated by the D2 signaling pathway respond to dopamine with an instantaneous increase in spike production. Increasing levels of dopamine concentrations around the cell body resulted in a dose dependent response, which resembles an “inverted U curve” (Vijayraghavan S, Wang M, Birnbaum SG, Williams GV, Arnsten AF (2007) Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory. Nat Neurosci 10:376-384), but this effect can easily be caused by an iontophoresis current artifact. Our present data imply that one population of PFC pyramidal neurons receiving direct synaptic contacts from midbrain dopaminergic neurons would stall during the 0.5 s of the phasic dopamine burst. The spillover dopamine, on the other hand, would act as a positive stimulator of cortical excitability (30% increase) to all D2-receptor carrying pyramidal cells, for the next 40 s." @default.
• W1981878280 created "2016-06-24" @default.
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• W1981878280 date "2011-01-01" @default.
• W1981878280 modified "2023-10-16" @default.
• W1981878280 title "Brief dopaminergic stimulations produce transient physiological changes in prefrontal pyramidal neurons" @default.
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• W1981878280 doi "https://doi.org/10.1016/j.brainres.2010.10.111" @default.
• W1981878280 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3019254" @default.
• W1981878280 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21059342" @default.
• W1981878280 hasPublicationYear "2011" @default.
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