Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981897188> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W1981897188 abstract "Abstract Ovarian neoplasms display a wide range of different phenotypic patterns. Recently, there has been much research that has identified the molecular genetic aberrations which are present in ovarian neoplasms, and that has linked these to the phenotypic patterns. Invasive ovarian carcinomas show complex genetic changes. Chromosomal gains at 3q26, 8q24 and 20q13 apparently represent early lesions, whereas loss of material of chromosomes 4, 13, 16, 18 and X is associated with tumour progression and poor prognosis. The main targets of chromosomal changes are regulatory genes of cell proliferation and apoptosis (e.g. p16, cyclin D1, Rb, p53, myc and bcl-2), and members of the signalling cascade of tyrosine kinase receptors (e.g. HER/2neu, dab-2, K-ras, PI3-K and PTEN). Granulosa cell tumours usually contain numeric chromosomal aberrations (monosomy 22, trisomy 12 and 14). The genetic alterations of ovarian neoplasms which have been described to date correlate with some aspects of the biological behaviour of these tumours. However, they do not fully explain the spectrum of phenotypic variability." @default.
- W1981897188 created "2016-06-24" @default.
- W1981897188 creator A5020223648 @default.
- W1981897188 creator A5083705585 @default.
- W1981897188 date "2003-10-01" @default.
- W1981897188 modified "2023-09-24" @default.
- W1981897188 title "Chromosomal changes in ovarian cancer" @default.
- W1981897188 cites W1611099852 @default.
- W1981897188 cites W1890251880 @default.
- W1981897188 cites W1912789001 @default.
- W1981897188 cites W1966269151 @default.
- W1981897188 cites W1966916604 @default.
- W1981897188 cites W1989487055 @default.
- W1981897188 cites W1998452076 @default.
- W1981897188 cites W2000562460 @default.
- W1981897188 cites W2012995477 @default.
- W1981897188 cites W2016756307 @default.
- W1981897188 cites W2019983709 @default.
- W1981897188 cites W2025839199 @default.
- W1981897188 cites W2045559903 @default.
- W1981897188 cites W2045945379 @default.
- W1981897188 cites W2069991737 @default.
- W1981897188 cites W2073799827 @default.
- W1981897188 cites W2079254825 @default.
- W1981897188 cites W2116497451 @default.
- W1981897188 cites W2125492990 @default.
- W1981897188 cites W2138493972 @default.
- W1981897188 cites W2142448075 @default.
- W1981897188 cites W2155197934 @default.
- W1981897188 cites W2200609520 @default.
- W1981897188 cites W2314290416 @default.
- W1981897188 cites W2406597704 @default.
- W1981897188 doi "https://doi.org/10.1016/s0968-6053(03)00050-4" @default.
- W1981897188 hasPublicationYear "2003" @default.
- W1981897188 type Work @default.
- W1981897188 sameAs 1981897188 @default.
- W1981897188 citedByCount "2" @default.
- W1981897188 crossrefType "journal-article" @default.
- W1981897188 hasAuthorship W1981897188A5020223648 @default.
- W1981897188 hasAuthorship W1981897188A5083705585 @default.
- W1981897188 hasConcept C101544691 @default.
- W1981897188 hasConcept C104317684 @default.
- W1981897188 hasConcept C121608353 @default.
- W1981897188 hasConcept C127716648 @default.
- W1981897188 hasConcept C184235292 @default.
- W1981897188 hasConcept C190283241 @default.
- W1981897188 hasConcept C199835354 @default.
- W1981897188 hasConcept C2777609662 @default.
- W1981897188 hasConcept C2779142324 @default.
- W1981897188 hasConcept C2780427987 @default.
- W1981897188 hasConcept C29537977 @default.
- W1981897188 hasConcept C30481170 @default.
- W1981897188 hasConcept C502942594 @default.
- W1981897188 hasConcept C53226629 @default.
- W1981897188 hasConcept C54355233 @default.
- W1981897188 hasConcept C86554907 @default.
- W1981897188 hasConcept C86803240 @default.
- W1981897188 hasConceptScore W1981897188C101544691 @default.
- W1981897188 hasConceptScore W1981897188C104317684 @default.
- W1981897188 hasConceptScore W1981897188C121608353 @default.
- W1981897188 hasConceptScore W1981897188C127716648 @default.
- W1981897188 hasConceptScore W1981897188C184235292 @default.
- W1981897188 hasConceptScore W1981897188C190283241 @default.
- W1981897188 hasConceptScore W1981897188C199835354 @default.
- W1981897188 hasConceptScore W1981897188C2777609662 @default.
- W1981897188 hasConceptScore W1981897188C2779142324 @default.
- W1981897188 hasConceptScore W1981897188C2780427987 @default.
- W1981897188 hasConceptScore W1981897188C29537977 @default.
- W1981897188 hasConceptScore W1981897188C30481170 @default.
- W1981897188 hasConceptScore W1981897188C502942594 @default.
- W1981897188 hasConceptScore W1981897188C53226629 @default.
- W1981897188 hasConceptScore W1981897188C54355233 @default.
- W1981897188 hasConceptScore W1981897188C86554907 @default.
- W1981897188 hasConceptScore W1981897188C86803240 @default.
- W1981897188 hasLocation W19818971881 @default.
- W1981897188 hasOpenAccess W1981897188 @default.
- W1981897188 hasPrimaryLocation W19818971881 @default.
- W1981897188 hasRelatedWork W1999506362 @default.
- W1981897188 hasRelatedWork W2034110171 @default.
- W1981897188 hasRelatedWork W2068614944 @default.
- W1981897188 hasRelatedWork W2965932022 @default.
- W1981897188 hasRelatedWork W2980855931 @default.
- W1981897188 hasRelatedWork W3029973090 @default.
- W1981897188 hasRelatedWork W3127795805 @default.
- W1981897188 hasRelatedWork W4283792134 @default.
- W1981897188 hasRelatedWork W4288801197 @default.
- W1981897188 hasRelatedWork W4224281256 @default.
- W1981897188 isParatext "false" @default.
- W1981897188 isRetracted "false" @default.
- W1981897188 magId "1981897188" @default.
- W1981897188 workType "article" @default.