Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981900522> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W1981900522 endingPage "709" @default.
- W1981900522 startingPage "699" @default.
- W1981900522 abstract "Tyrosyl-tRNA synthetase from Bacillus stearothermophilus is a dimeric molecule of approximately 90,000 Mr. The crystal structure originally reported by Irwin et al. (1976) has been re-interpreted using a new density-modification technique. The reinterpretation is confirmed by the complete amino acid sequence (D. Barker & (G. Winter, personal communication). The structure consists of an amino-terminal αβ domain, a domain containing five α-helices, and a region of 99 amino acids at the carboxyl terminus, which appears to be disordered. The re-interpretation reveals two new α-helices in the αβ domain, and some changes in chain connections. The strands of the β-sheet are in the order A, F, E, B, C, D, with A antiparallel to the others. The arrangement of strands B to F is topologically identical to arrangements found in many other proteins, including the first five strands of the sheet in the NAD-binding domain of the dehydrogenases. Strands B, C, D form a mononucleotide-binding fold. In the complex with tyrosyl adenylate (Rubin & Blow, 1981), an intermediate in the reaction catalysed by the enzyme, the adenine lies near the carboxyl-terminal end of strand F of the β-sheet, with the ribose between the ends of strands B and E. This is similar to the nicotinamide position in dehydrogenases. The tyrosine moiety occupies a pocket at one side of the sheet, close to strands B and C. This tyrosine orientation is quite different from any part of the coenzyme in dehydrogenases. The ends of strands C and D of the sheet are buried, and binding of a nucleotide to the mononucleotide-binding fold formed by strands B, C, D would require a substantial structural change." @default.
- W1981900522 created "2016-06-24" @default.
- W1981900522 creator A5029945783 @default.
- W1981900522 creator A5076997623 @default.
- W1981900522 creator A5079526758 @default.
- W1981900522 creator A5085120671 @default.
- W1981900522 date "1982-07-01" @default.
- W1981900522 modified "2023-09-24" @default.
- W1981900522 title "Tyrosyl-tRNA synthetase forms a mononucleotide-binding fold" @default.
- W1981900522 cites W1598617551 @default.
- W1981900522 cites W1963683128 @default.
- W1981900522 cites W1975450658 @default.
- W1981900522 cites W1988421239 @default.
- W1981900522 cites W2000388754 @default.
- W1981900522 cites W2016430343 @default.
- W1981900522 cites W2026046929 @default.
- W1981900522 cites W2026159762 @default.
- W1981900522 cites W2032916773 @default.
- W1981900522 cites W2045673319 @default.
- W1981900522 cites W2060728728 @default.
- W1981900522 cites W2061124135 @default.
- W1981900522 cites W2061252795 @default.
- W1981900522 cites W2064379284 @default.
- W1981900522 cites W2067976949 @default.
- W1981900522 cites W2074362388 @default.
- W1981900522 cites W2091313066 @default.
- W1981900522 cites W2099950967 @default.
- W1981900522 cites W2170061656 @default.
- W1981900522 cites W2178012333 @default.
- W1981900522 cites W2320403957 @default.
- W1981900522 doi "https://doi.org/10.1016/0022-2836(82)90255-8" @default.
- W1981900522 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7120416" @default.
- W1981900522 hasPublicationYear "1982" @default.
- W1981900522 type Work @default.
- W1981900522 sameAs 1981900522 @default.
- W1981900522 citedByCount "146" @default.
- W1981900522 countsByYear W19819005222012 @default.
- W1981900522 countsByYear W19819005222013 @default.
- W1981900522 countsByYear W19819005222014 @default.
- W1981900522 crossrefType "journal-article" @default.
- W1981900522 hasAuthorship W1981900522A5029945783 @default.
- W1981900522 hasAuthorship W1981900522A5076997623 @default.
- W1981900522 hasAuthorship W1981900522A5079526758 @default.
- W1981900522 hasAuthorship W1981900522A5085120671 @default.
- W1981900522 hasConcept C115260700 @default.
- W1981900522 hasConcept C121332964 @default.
- W1981900522 hasConcept C142089489 @default.
- W1981900522 hasConcept C159547669 @default.
- W1981900522 hasConcept C181199279 @default.
- W1981900522 hasConcept C185592680 @default.
- W1981900522 hasConcept C197957613 @default.
- W1981900522 hasConcept C2776165026 @default.
- W1981900522 hasConcept C47701112 @default.
- W1981900522 hasConcept C515207424 @default.
- W1981900522 hasConcept C55493867 @default.
- W1981900522 hasConcept C62520636 @default.
- W1981900522 hasConcept C71240020 @default.
- W1981900522 hasConcept C8010536 @default.
- W1981900522 hasConceptScore W1981900522C115260700 @default.
- W1981900522 hasConceptScore W1981900522C121332964 @default.
- W1981900522 hasConceptScore W1981900522C142089489 @default.
- W1981900522 hasConceptScore W1981900522C159547669 @default.
- W1981900522 hasConceptScore W1981900522C181199279 @default.
- W1981900522 hasConceptScore W1981900522C185592680 @default.
- W1981900522 hasConceptScore W1981900522C197957613 @default.
- W1981900522 hasConceptScore W1981900522C2776165026 @default.
- W1981900522 hasConceptScore W1981900522C47701112 @default.
- W1981900522 hasConceptScore W1981900522C515207424 @default.
- W1981900522 hasConceptScore W1981900522C55493867 @default.
- W1981900522 hasConceptScore W1981900522C62520636 @default.
- W1981900522 hasConceptScore W1981900522C71240020 @default.
- W1981900522 hasConceptScore W1981900522C8010536 @default.
- W1981900522 hasIssue "4" @default.
- W1981900522 hasLocation W19819005221 @default.
- W1981900522 hasLocation W19819005222 @default.
- W1981900522 hasOpenAccess W1981900522 @default.
- W1981900522 hasPrimaryLocation W19819005221 @default.
- W1981900522 hasRelatedWork W1968295792 @default.
- W1981900522 hasRelatedWork W2025494960 @default.
- W1981900522 hasRelatedWork W2042555229 @default.
- W1981900522 hasRelatedWork W2046171556 @default.
- W1981900522 hasRelatedWork W2069852256 @default.
- W1981900522 hasRelatedWork W2095169134 @default.
- W1981900522 hasRelatedWork W2102600999 @default.
- W1981900522 hasRelatedWork W2123195323 @default.
- W1981900522 hasRelatedWork W2132429545 @default.
- W1981900522 hasRelatedWork W2166503747 @default.
- W1981900522 hasVolume "158" @default.
- W1981900522 isParatext "false" @default.
- W1981900522 isRetracted "false" @default.
- W1981900522 magId "1981900522" @default.
- W1981900522 workType "article" @default.