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- W1981905359 abstract "MicroRNAs are a class of short noncoding RNAs that are involved in various biological processes, including differentiation. MicroRNA-140 (miR-140) has been identified as a cartilage-specific microRNA with several targets involved in cartilage development and homeostasis. The aim of this study was to investigate the expression of miR-140 during chondrogenic differentiation of equine cord blood-derived mesenchymal stromal cells (eCB-MSCs). We demonstrate both that miR-140 is highly expressed in normal equine articular cartilage and that eCB-MSCs express significantly higher levels of this microRNA after 14 days of chondrogenic differentiation. Furthermore, miR-140 expression closely paralleled that of the cartilage-specific transcription factor Sox9, suggesting that miR-140 may be under the transcriptional regulation of Sox9 in these cells. The expression patterns of miR-140 targets the chemokine (CXC motif) ligand 12 (CXCL12), A disintegrin and metalloproteinase with thrombosponin motifs (ADAMTS)-5 and insulin growth factor binding protein 5 (IGFBP5) were also determined; however, only CXCL12 and ADAMTS-5 were repressed while miR-140 expression was upregulated. Together, these studies suggest that miR-140 is an important regulator of cartilage development and homeostasis in eCB-MSCs that may act, in part, through the regulation of CXCL12 and ADAMTS-5." @default.
- W1981905359 created "2016-06-24" @default.
- W1981905359 creator A5008449484 @default.
- W1981905359 creator A5071612808 @default.
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- W1981905359 date "2013-04-15" @default.
- W1981905359 modified "2023-09-27" @default.
- W1981905359 title "MicroRNA-140 Expression During Chondrogenic Differentiation of Equine Cord Blood-Derived Mesenchymal Stromal Cells" @default.
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- W1981905359 doi "https://doi.org/10.1089/scd.2012.0411" @default.
- W1981905359 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23157248" @default.
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