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• W1981906564 abstract "Bioactive nanocomposite of nonstoichiometric apatite (ns-AP) and poly(ε-caprolactone) (PCL) was synthesized and its porous scaffold was fabricated. The results show that the hydrophilicity and cell attachment ratio on the composite surface improved with the increase of ns-AP content in PCL. The composite scaffolds with 60 wt % ns-AP content contained open and interconnected pores ranging in size from 200 to 500 μm and exhibit a porosity of around 80%. In addition, proliferation of MG63 cells on the composite scaffolds significantly increased with the increase of ns-AP content, and the level of alkaline phosphatase (ALP) activity and nitric oxide (NO) production of the cells cultured on the composite scaffold were higher than that of PCL at 7 days, revealing that the composite scaffolds had excellent in vitro biocompatibility and bioactivity. The composite scaffolds were implanted into rabbit mandible defects, the results suggest that the introduction of ns-AP into PCL enhanced the efficiency of new bone formation, and the ns-AP/PCL composite exhibited in vivo good biocompatibility and osteogenesis. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2010" @default.
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• W1981906564 date "2009-01-01" @default.
• W1981906564 modified "2023-09-23" @default.
• W1981906564 title "Fabrication and biocompatibility of porously bioactive scaffold of nonstoichiometric apatite and poly(ε-caprolactone) nanocomposite" @default.
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• W1981906564 doi "https://doi.org/10.1002/app.31466" @default.
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