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- W1981920912 abstract "The immunoregulatory cytokine interleukin 10 (IL-10) is expressed mainly by T helper type 2 (T(H)2) cells but also by T(H)1 cells during chronic infection. Here we observed plasticity in the expression of IL-10 and IL-13 after chronic T(H)1 stimulation; furthermore, the expression of Il10 and Il13 was regulated by the transcription factor E4BP4. Chronically stimulated E4BP4-deficient (Nfil3(-/-); called 'E4bp4(-/-)' here) T(H)1 cells, regulatory T cells (T(reg) cells) and natural killer T cells (NKT cells) had attenuated expression of IL-10 and IL-13. Enforced expression of E4bp4 initiated the production of IL-10 and IL-13 by conventional T(H)1 cells. E4bp4(-/-) T(H)2 cells showed impairment of IL-10 production with no effect on IL-13. Our results indicate that E4BP4 has multiple functions in controlling the plasticity of IL-13 in T(H)1 cells and IL-10 in T(H)1 cells, T(H)2 cells, T(reg) cells and NKT cells." @default.
- W1981920912 created "2016-06-24" @default.
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- W1981920912 date "2011-04-03" @default.
- W1981920912 modified "2023-10-06" @default.
- W1981920912 title "The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells" @default.
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- W1981920912 doi "https://doi.org/10.1038/ni.2020" @default.
- W1981920912 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3494493" @default.
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