Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981933748> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W1981933748 endingPage "1661" @default.
- W1981933748 startingPage "1661" @default.
- W1981933748 abstract "A method is described for the simultaneous determination of the rates of regional cerebral blood flow (rCBF) and regional cerebral glucose utilization (rCMRgl) in 6–7 mg brain samples dissected from multiple areas of interest. The method utilizes [131I]-iodoantipyrine ([131l]IAP) to measure rCBF by indicator fractionation, and [14C]2-deoxyglucose to measure rCMRgl. [131I]IAP was synthesized with specific activity exceeding 350 Ci/mmol and radiochemical purity greater than 99.5% by the radioiodination of antipyrine with Na131I. A triple-counting strategy was developed to quantitate14C activity of the dissected brain samples in the presence of131I. The factors contributing to the propagated error of the double-label separation strategy were defined and optimal assay parameters were determined. The separation strategy was validated by measuring rCBF simultaneously with both [131I]IAP (x) and [14C]IAP (y) in a series of rats. The equation of the regression line was y = 1.025 x −0.065 (correlation coefficient 0.985), denoting excellent agreement. In another series of 5 normocapnic rats anesthetized with nitrous oxide, rCBF and rCMRgl were measured simultaneously. In individual animals, the rates of rCBF within 14–16 brain areas were closely coupled to their respective rates of glucose metabolism. For the group data, the linear regression equation relating rCBF (y) to rCMRgl (x) was y = 1.76 x + 0.13 (correlation coefficient 0.93,P < 0.001). These studies provide direct evidence, based upon data obtained in the same brain, of a close coupling of regional metabolic rate and blood flow." @default.
- W1981933748 created "2016-06-24" @default.
- W1981933748 creator A5003686224 @default.
- W1981933748 creator A5010117936 @default.
- W1981933748 creator A5037890172 @default.
- W1981933748 creator A5045228728 @default.
- W1981933748 date "1984-06-01" @default.
- W1981933748 modified "2023-09-23" @default.
- W1981933748 title "Radioiodine therapy and serum lats-protector." @default.
- W1981933748 doi "https://doi.org/10.1016/0022-4731(84)91002-1" @default.
- W1981933748 hasPublicationYear "1984" @default.
- W1981933748 type Work @default.
- W1981933748 sameAs 1981933748 @default.
- W1981933748 citedByCount "0" @default.
- W1981933748 crossrefType "journal-article" @default.
- W1981933748 hasAuthorship W1981933748A5003686224 @default.
- W1981933748 hasAuthorship W1981933748A5010117936 @default.
- W1981933748 hasAuthorship W1981933748A5037890172 @default.
- W1981933748 hasAuthorship W1981933748A5045228728 @default.
- W1981933748 hasConcept C105795698 @default.
- W1981933748 hasConcept C126322002 @default.
- W1981933748 hasConcept C134018914 @default.
- W1981933748 hasConcept C152877465 @default.
- W1981933748 hasConcept C157767197 @default.
- W1981933748 hasConcept C185592680 @default.
- W1981933748 hasConcept C2780092901 @default.
- W1981933748 hasConcept C2989005 @default.
- W1981933748 hasConcept C2992768293 @default.
- W1981933748 hasConcept C33923547 @default.
- W1981933748 hasConcept C43617362 @default.
- W1981933748 hasConcept C48921125 @default.
- W1981933748 hasConcept C71924100 @default.
- W1981933748 hasConcept C89838059 @default.
- W1981933748 hasConcept C97428945 @default.
- W1981933748 hasConceptScore W1981933748C105795698 @default.
- W1981933748 hasConceptScore W1981933748C126322002 @default.
- W1981933748 hasConceptScore W1981933748C134018914 @default.
- W1981933748 hasConceptScore W1981933748C152877465 @default.
- W1981933748 hasConceptScore W1981933748C157767197 @default.
- W1981933748 hasConceptScore W1981933748C185592680 @default.
- W1981933748 hasConceptScore W1981933748C2780092901 @default.
- W1981933748 hasConceptScore W1981933748C2989005 @default.
- W1981933748 hasConceptScore W1981933748C2992768293 @default.
- W1981933748 hasConceptScore W1981933748C33923547 @default.
- W1981933748 hasConceptScore W1981933748C43617362 @default.
- W1981933748 hasConceptScore W1981933748C48921125 @default.
- W1981933748 hasConceptScore W1981933748C71924100 @default.
- W1981933748 hasConceptScore W1981933748C89838059 @default.
- W1981933748 hasConceptScore W1981933748C97428945 @default.
- W1981933748 hasIssue "6" @default.
- W1981933748 hasLocation W19819337481 @default.
- W1981933748 hasOpenAccess W1981933748 @default.
- W1981933748 hasPrimaryLocation W19819337481 @default.
- W1981933748 hasRelatedWork W1489210197 @default.
- W1981933748 hasRelatedWork W1895240347 @default.
- W1981933748 hasRelatedWork W1973404346 @default.
- W1981933748 hasRelatedWork W1976388830 @default.
- W1981933748 hasRelatedWork W2003782122 @default.
- W1981933748 hasRelatedWork W2123776185 @default.
- W1981933748 hasRelatedWork W2412061064 @default.
- W1981933748 hasRelatedWork W2415870354 @default.
- W1981933748 hasRelatedWork W3150051254 @default.
- W1981933748 hasRelatedWork W4291492812 @default.
- W1981933748 hasVolume "20" @default.
- W1981933748 isParatext "false" @default.
- W1981933748 isRetracted "false" @default.
- W1981933748 magId "1981933748" @default.
- W1981933748 workType "article" @default.