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- W1981939873 abstract "Purpose: The aim of this study was to investigate the relation between interleukin (IL) 10, tumor necrosis factor alpha (TNFα), IL-1, and IL-6 levels in patients with septic shock and relate these cytokine levels to the development of organ failure. Patients and Methods: In 11 patients with septic shock of recent onset, blood was sampled for determinations of TNF, IL-1, IL-6, and IL-10. The degree of organ failure was scored for four organ systems (respiratory, hepatic, renal, hematologic) in the first 48 hours of the study. Results: The APACHE II score was 21 ± 4. Three patients died. IL-10 levels were directly correlated with TNF levels (r = 0.73, P < .05) and IL-6 levels (r = 0.67, P < .05); and inversely correlated with total C3 (r = −0.73, P < .05) and CH50 (r = −0.68, P < .05). Both IL-10 and TNF levels were correlated to the organ failure score (r = 0.75 and r = 0.68, both P < .01). Six patients with high IL-10 levels (>60 pg/mL) had lower C3 (37 ± 11 v 62 ± 10 mg/dL) and CH50 (32 ± 7 v 68 ± 19%), and higher organ failure scores (5.7 ± 0.8 v 3.8 ± 1.3) than those with low IL-10 levels (all P < .05). Conclusion: Although IL-10 has an inhibitory effect on the production of cytokines, it is released together with TNF and IL-6 in patients with septic shock. IL-10 blood levels are directly related to the severity of inflammation and the development of organ failure in septic shock." @default.
- W1981939873 created "2016-06-24" @default.
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- W1981939873 date "1997-12-01" @default.
- W1981939873 modified "2023-10-18" @default.
- W1981939873 title "Blood interleukin 10 levels parallel the severity of septic shock" @default.
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- W1981939873 doi "https://doi.org/10.1016/s0883-9441(97)90030-7" @default.
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