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- W1981952601 abstract "Background Cardiac myocyte sarcolemma contains both catecholamine and opioid peptide receptors (OPRs). Opioid peptides are coreleased with catecholamines from nerve terminals in the heart. We investigated whether OPR stimulation influences the effects of β-adrenergic receptor (β-AR) stimulation in the isolated, isovolumic rat heart and whether the mechanism of such an interaction involves both β-AR subtypes or an alteration in β-AR–mediated increase in cAMP. Methods and Results Norepinephrine (NE, 10 −7 mol/L) increased peak left ventricular systolic pressure (LVSP) and cAMP more than twofold compared with controls. The δ-OPR agonist leucine-enkephalin (LE, 10 −8 mol/L) markedly inhibited the β 1 -AR–induced positive inotropic effect and increase in cAMP but alone had no effect on basal LVSP or basal cAMP levels. The OPR antagonist naloxone 10 −8 mol/L added to LE+NE perfusate reversed the LE-induced decrease in cAMP and LVSP even though naloxone alone had no effect on LVSP and cAMP levels. LE could not counteract the twofold increase in LVSP produced by the nondegradable cAMP analog CPTcAMP 2.3×10 −5 mol/L or a high concentration of forskolin (10 −7 mol/L) but did reverse the 173±11.8% and 135±13.6% increases in LVSP stimulated by 10 −8 and 0.5×10 −8 mol/L forskolin, respectively. LE inhibited cAMP production at all concentrations of forskolin (10 −7 , 10 −8 , and 0.5×10 −8 mol/L). Pertussis toxin (PTX) pretreatment abolished LE effects on β 1 -AR stimulation. Zinterol 10 −5 and 10 −6 mol/L, a specific β 2 -AR agonist that elicits a cAMP-independent inotropic effect in rat heart, caused 225±14% and 182±5% increases in LVSP that could not be reversed by addition of LE. Conclusions Potent, inhibitory “cross talk” between δ-OPR and β 1 -AR signaling pathways occurs via a PTX-sensitive G i/o protein involved in adenylyl cyclase inhibition in rat heart." @default.
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- W1981952601 date "1997-04-15" @default.
- W1981952601 modified "2023-10-15" @default.
- W1981952601 title "‘Cross Talk’ Between Opioid Peptide and Adrenergic Receptor Signaling in Isolated Rat Heart" @default.
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- W1981952601 doi "https://doi.org/10.1161/01.cir.95.8.2122" @default.
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