Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981967543> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W1981967543 endingPage "159" @default.
- W1981967543 startingPage "151" @default.
- W1981967543 abstract "Abstract Background: interferon-α is able to induce a sustained inhibition of hepatitis B virus replication in about 30–40% of patients with chronic hepatitis B. There is evidence that non-steroidal antiinflammatory drugs can enhance the synthesis of antiviral proteins induced by interferon-α, Aim: to evaluate the efficacy and tolerability of combined therapy with interferon-α plus indomethacin in HBeAg and HBV-DNA positive patients affected by chronic active hepatitis non-responders to a previous interferon-α treatment. Methods: after six months of retreatment with interferon-α (6 MU thrice weekly) six patients were enrolled, without stopping the therapy, to receive interferon-α (with the same schedule) plus indomethacin (25 mg orally twice daily) for an additional six month course. Results: at the end of treatment and after six months of follow-up alanine transaminase normalization was seen in three (50%) and four (66.7%) patients, HBV-DNA loss in one (17%) and three (50%), HBeAg HBeAb serum conversion in one (17%) and two (33%), respectively. The combined therapy was well tolerated and no indomethacin side-effects were observed. The treatment was stopped in one patient after 4 months because of a remarkable increase of alanine transaminase levels, and in another after five months because of hyperthyroidism occurrence. Conclusions: the results of this study, even if obtained in a small number of patients, are encouraging and suggest a randomized controlled trial to be confirmed." @default.
- W1981967543 created "2016-06-24" @default.
- W1981967543 creator A5025865489 @default.
- W1981967543 creator A5028979280 @default.
- W1981967543 creator A5032296033 @default.
- W1981967543 creator A5062155863 @default.
- W1981967543 creator A5065875744 @default.
- W1981967543 creator A5089713793 @default.
- W1981967543 date "1996-07-01" @default.
- W1981967543 modified "2023-09-23" @default.
- W1981967543 title "Interferon-? plus indomethacin combined therapy in HBeAg positive chronic hepatitis B non-responder to a previous IFN? course: results of a pilot study" @default.
- W1981967543 cites W1563827978 @default.
- W1981967543 cites W1950099322 @default.
- W1981967543 cites W1977223965 @default.
- W1981967543 cites W1978009452 @default.
- W1981967543 cites W1978977060 @default.
- W1981967543 cites W1992782405 @default.
- W1981967543 cites W2003388804 @default.
- W1981967543 cites W2022593799 @default.
- W1981967543 cites W2023766595 @default.
- W1981967543 cites W2024230468 @default.
- W1981967543 cites W2032315733 @default.
- W1981967543 cites W2054694308 @default.
- W1981967543 cites W2055043707 @default.
- W1981967543 cites W2077601302 @default.
- W1981967543 cites W2082897563 @default.
- W1981967543 cites W2115956200 @default.
- W1981967543 cites W2142032585 @default.
- W1981967543 cites W2157392969 @default.
- W1981967543 cites W2341203768 @default.
- W1981967543 cites W437178797 @default.
- W1981967543 doi "https://doi.org/10.1016/0928-4346(96)00286-1" @default.
- W1981967543 hasPublicationYear "1996" @default.
- W1981967543 type Work @default.
- W1981967543 sameAs 1981967543 @default.
- W1981967543 citedByCount "4" @default.
- W1981967543 crossrefType "journal-article" @default.
- W1981967543 hasAuthorship W1981967543A5025865489 @default.
- W1981967543 hasAuthorship W1981967543A5028979280 @default.
- W1981967543 hasAuthorship W1981967543A5032296033 @default.
- W1981967543 hasAuthorship W1981967543A5062155863 @default.
- W1981967543 hasAuthorship W1981967543A5065875744 @default.
- W1981967543 hasAuthorship W1981967543A5089713793 @default.
- W1981967543 hasConcept C126322002 @default.
- W1981967543 hasConcept C203014093 @default.
- W1981967543 hasConcept C2522874641 @default.
- W1981967543 hasConcept C2775940106 @default.
- W1981967543 hasConcept C2776178377 @default.
- W1981967543 hasConcept C2777410769 @default.
- W1981967543 hasConcept C2780593183 @default.
- W1981967543 hasConcept C3020491458 @default.
- W1981967543 hasConcept C71924100 @default.
- W1981967543 hasConcept C90924648 @default.
- W1981967543 hasConceptScore W1981967543C126322002 @default.
- W1981967543 hasConceptScore W1981967543C203014093 @default.
- W1981967543 hasConceptScore W1981967543C2522874641 @default.
- W1981967543 hasConceptScore W1981967543C2775940106 @default.
- W1981967543 hasConceptScore W1981967543C2776178377 @default.
- W1981967543 hasConceptScore W1981967543C2777410769 @default.
- W1981967543 hasConceptScore W1981967543C2780593183 @default.
- W1981967543 hasConceptScore W1981967543C3020491458 @default.
- W1981967543 hasConceptScore W1981967543C71924100 @default.
- W1981967543 hasConceptScore W1981967543C90924648 @default.
- W1981967543 hasIssue "3" @default.
- W1981967543 hasLocation W19819675431 @default.
- W1981967543 hasOpenAccess W1981967543 @default.
- W1981967543 hasPrimaryLocation W19819675431 @default.
- W1981967543 hasRelatedWork W2352700173 @default.
- W1981967543 hasRelatedWork W2360664584 @default.
- W1981967543 hasRelatedWork W2361788420 @default.
- W1981967543 hasRelatedWork W2373763932 @default.
- W1981967543 hasRelatedWork W2374742072 @default.
- W1981967543 hasRelatedWork W2374881860 @default.
- W1981967543 hasRelatedWork W2385819297 @default.
- W1981967543 hasRelatedWork W2386846656 @default.
- W1981967543 hasRelatedWork W2946507003 @default.
- W1981967543 hasRelatedWork W3151192819 @default.
- W1981967543 hasVolume "5" @default.
- W1981967543 isParatext "false" @default.
- W1981967543 isRetracted "false" @default.
- W1981967543 magId "1981967543" @default.
- W1981967543 workType "article" @default.