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- W1981976406 abstract "The development of personalized medicine with a focus on novel targeted therapies has supplanted the one-size-fits-all approach to the treatment of many cancers, including non-small cell lung cancer. Targeted therapies, if given to a patient subpopulation enriched by the presence of relevant molecular targets, can often abrogate cell signaling that perpetuates cancer progression. Critical targets activating procancer pathways include, but are not limited to, epidermal growth factor receptor (EGFR), hepatocyte growth factor receptor (MET), vascular endothelial growth factor (VEGF), VEGF receptor, GTPase KRAS (KRAS), receptor tyrosine protein kinase erbB-2 (HER2), echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA), serine/threonine-protein kinase B-raf (BRAF), and insulin-like growth factor 1 receptor (IGF-1R). Some target-directed therapies, such as epidermal growth factor receptor tyrosine kinase inhibitors and anti-VEGF monoclonal antibody, have already been approved for clinical use. Others, such as those targeted to MET, VEGFR, HER2, PIK3CA, and IGF-1R, are in clinical testing. This review describes molecular targets in non-small cell lung cancer that are in development or being clinically applied and their implications for developing novel anticancer therapies for this previously refractory malignancy." @default.
- W1981976406 created "2016-06-24" @default.
- W1981976406 creator A5000705184 @default.
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- W1981976406 creator A5071800834 @default.
- W1981976406 date "2011-09-01" @default.
- W1981976406 modified "2023-10-18" @default.
- W1981976406 title "Novel Therapeutic Targets in Non-small Cell Lung Cancer" @default.
- W1981976406 cites W1839975169 @default.
- W1981976406 cites W1964321121 @default.
- W1981976406 cites W1966738726 @default.
- W1981976406 cites W1969525589 @default.
- W1981976406 cites W1970476748 @default.
- W1981976406 cites W1979101646 @default.
- W1981976406 cites W1979332174 @default.
- W1981976406 cites W1980497534 @default.
- W1981976406 cites W1984852348 @default.
- W1981976406 cites W1989773675 @default.
- W1981976406 cites W1991341116 @default.
- W1981976406 cites W1998971866 @default.
- W1981976406 cites W2001999652 @default.
- W1981976406 cites W2003984225 @default.
- W1981976406 cites W2007661090 @default.
- W1981976406 cites W2015015957 @default.
- W1981976406 cites W2015416126 @default.
- W1981976406 cites W2027266396 @default.
- W1981976406 cites W2031494655 @default.
- W1981976406 cites W2043696829 @default.
- W1981976406 cites W2049449785 @default.
- W1981976406 cites W2054633892 @default.
- W1981976406 cites W2055402151 @default.
- W1981976406 cites W2055787036 @default.
- W1981976406 cites W2056837471 @default.
- W1981976406 cites W2059918712 @default.
- W1981976406 cites W2072185965 @default.
- W1981976406 cites W2082592896 @default.
- W1981976406 cites W2092741708 @default.
- W1981976406 cites W2092897704 @default.
- W1981976406 cites W2093613683 @default.
- W1981976406 cites W2093922887 @default.
- W1981976406 cites W2094882473 @default.
- W1981976406 cites W2095253562 @default.
- W1981976406 cites W2095618958 @default.
- W1981976406 cites W2096786080 @default.
- W1981976406 cites W2100439220 @default.
- W1981976406 cites W2100912832 @default.
- W1981976406 cites W2101329867 @default.
- W1981976406 cites W2102590541 @default.
- W1981976406 cites W2104224322 @default.
- W1981976406 cites W2104339838 @default.
- W1981976406 cites W2104748005 @default.
- W1981976406 cites W2104830962 @default.
- W1981976406 cites W2105026490 @default.
- W1981976406 cites W2105834225 @default.
- W1981976406 cites W2106543129 @default.
- W1981976406 cites W2107304950 @default.
- W1981976406 cites W2107666024 @default.
- W1981976406 cites W2110280804 @default.
- W1981976406 cites W2110835998 @default.
- W1981976406 cites W2110841878 @default.
- W1981976406 cites W2111191667 @default.
- W1981976406 cites W2112660136 @default.
- W1981976406 cites W2114642822 @default.
- W1981976406 cites W2115078104 @default.
- W1981976406 cites W2115330744 @default.
- W1981976406 cites W2117527810 @default.
- W1981976406 cites W2118073504 @default.
- W1981976406 cites W2119209952 @default.
- W1981976406 cites W2123611729 @default.
- W1981976406 cites W2124189018 @default.
- W1981976406 cites W2124464299 @default.
- W1981976406 cites W2127101185 @default.
- W1981976406 cites W2129360604 @default.
- W1981976406 cites W2130254323 @default.
- W1981976406 cites W2130982149 @default.
- W1981976406 cites W2132157071 @default.
- W1981976406 cites W2133867160 @default.
- W1981976406 cites W2136137911 @default.
- W1981976406 cites W2138297714 @default.
- W1981976406 cites W2139110945 @default.
- W1981976406 cites W2139438052 @default.
- W1981976406 cites W2139720565 @default.
- W1981976406 cites W2140088548 @default.
- W1981976406 cites W2142459600 @default.
- W1981976406 cites W2142850084 @default.
- W1981976406 cites W2143859186 @default.
- W1981976406 cites W2144012034 @default.
- W1981976406 cites W2144323242 @default.
- W1981976406 cites W2144660856 @default.
- W1981976406 cites W2145835533 @default.
- W1981976406 cites W2148174696 @default.
- W1981976406 cites W2148479145 @default.
- W1981976406 cites W2152755651 @default.
- W1981976406 cites W2153477391 @default.
- W1981976406 cites W2154402764 @default.
- W1981976406 cites W2155946891 @default.