FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1981990410> ?p ?o ?g. }

• W1981990410 endingPage "1485" @default.
• W1981990410 startingPage "1481" @default.
• W1981990410 abstract "To analyze in severely obese women the circadian expression of the clock genes hPer2, hBmal1, and hCry1 in explants from subcutaneous (SAT) and visceral (VAT) adipose tissue (AT), in order to elucidate whether this circadian clockwork can oscillate accurately and independently of the suprachiasmatic nucleus (SCN) and if glucocorticoid metabolism-related genes such as glucocorticoid receptor (hGr) and 11β-hydroxysteroid dehydrogenase 1 (h11βHsd1) and the transcription factor peroxisome proliferator activated receptor γ (hPPARγ) are part of the clock controlled genes. AT biopsies were obtained from morbid obese patients (BMI ≥40 kg/m2) (n = 7). Anthropometric variables were measured and fasting plasma lipids and lipoprotein concentrations were analyzed. In order to carry out rhythmic expression analysis, AT explants were cultured during 24 h and gene expression was performed at the following times (T): 0, 6, 12, and 18 h, with quantitative real-time PCR. Clock genes oscillated accurately and independently of the SCN in AT explants. Their intrinsic oscillatory mechanism regulated the timing of other genes such as hPPARγ and glucocorticoid-related genes. Circadian patterns differed between VAT and SAT. Correlation analyses between the genetic circadian oscillation and components of the metabolic syndrome (MetS) revealed that subjects with a higher sagittal diameter showed an increased circadian variability in hPer2 expression (r = 0.91; P = 0.031) and hBmal1 (r = 0.90; P = 0.040). Data demonstrate the presence of peripheral circadian oscillators in human AT independently of the central circadian control mechanism. This knowledge paves the way for a better understanding of the circadian contribution to medical conditions such as obesity and MetS." @default.
• W1981990410 created "2016-06-24" @default.
• W1981990410 creator A5008253051 @default.
• W1981990410 creator A5016204613 @default.
• W1981990410 creator A5019542047 @default.
• W1981990410 creator A5036285087 @default.
• W1981990410 creator A5050906368 @default.
• W1981990410 creator A5073235477 @default.
• W1981990410 creator A5091504821 @default.
• W1981990410 date "2009-08-01" @default.
• W1981990410 modified "2023-10-17" @default.
• W1981990410 title "Circadian Rhythm of Clock Genes in Human Adipose Explants" @default.
• W1981990410 cites W2000941854 @default.
• W1981990410 cites W2003302378 @default.
• W1981990410 cites W2016424285 @default.
• W1981990410 cites W2024493318 @default.
• W1981990410 cites W2024536570 @default.
• W1981990410 cites W2040629892 @default.
• W1981990410 cites W2040650438 @default.
• W1981990410 cites W2045092934 @default.
• W1981990410 cites W2048457027 @default.
• W1981990410 cites W2060925737 @default.
• W1981990410 cites W2073293204 @default.
• W1981990410 cites W2074046570 @default.
• W1981990410 cites W2103117061 @default.
• W1981990410 cites W2104712753 @default.
• W1981990410 cites W2107277218 @default.
• W1981990410 cites W2108988707 @default.
• W1981990410 cites W2113297137 @default.
• W1981990410 cites W2130717716 @default.
• W1981990410 cites W2135501576 @default.
• W1981990410 cites W2137414457 @default.
• W1981990410 cites W2145016852 @default.
• W1981990410 cites W2150085983 @default.
• W1981990410 cites W2154114022 @default.
• W1981990410 cites W2157952872 @default.
• W1981990410 cites W2169005423 @default.
• W1981990410 doi "https://doi.org/10.1038/oby.2009.164" @default.
• W1981990410 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4429875" @default.
• W1981990410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19478785" @default.
• W1981990410 hasPublicationYear "2009" @default.
• W1981990410 type Work @default.
• W1981990410 sameAs 1981990410 @default.
• W1981990410 citedByCount "106" @default.
• W1981990410 countsByYear W19819904102012 @default.
• W1981990410 countsByYear W19819904102013 @default.
• W1981990410 countsByYear W19819904102014 @default.
• W1981990410 countsByYear W19819904102015 @default.
• W1981990410 countsByYear W19819904102016 @default.
• W1981990410 countsByYear W19819904102017 @default.
• W1981990410 countsByYear W19819904102018 @default.
• W1981990410 countsByYear W19819904102019 @default.
• W1981990410 countsByYear W19819904102020 @default.
• W1981990410 countsByYear W19819904102021 @default.
• W1981990410 countsByYear W19819904102022 @default.
• W1981990410 countsByYear W19819904102023 @default.
• W1981990410 crossrefType "journal-article" @default.
• W1981990410 hasAuthorship W1981990410A5008253051 @default.
• W1981990410 hasAuthorship W1981990410A5016204613 @default.
• W1981990410 hasAuthorship W1981990410A5019542047 @default.
• W1981990410 hasAuthorship W1981990410A5036285087 @default.
• W1981990410 hasAuthorship W1981990410A5050906368 @default.
• W1981990410 hasAuthorship W1981990410A5073235477 @default.
• W1981990410 hasAuthorship W1981990410A5091504821 @default.
• W1981990410 hasBestOaLocation W19819904101 @default.
• W1981990410 hasConcept C121446783 @default.
• W1981990410 hasConcept C126322002 @default.
• W1981990410 hasConcept C134018914 @default.
• W1981990410 hasConcept C171089720 @default.
• W1981990410 hasConcept C184738001 @default.
• W1981990410 hasConcept C2779317972 @default.
• W1981990410 hasConcept C2780841215 @default.
• W1981990410 hasConcept C38606739 @default.
• W1981990410 hasConcept C59493245 @default.
• W1981990410 hasConcept C71924100 @default.
• W1981990410 hasConcept C86803240 @default.
• W1981990410 hasConceptScore W1981990410C121446783 @default.
• W1981990410 hasConceptScore W1981990410C126322002 @default.
• W1981990410 hasConceptScore W1981990410C134018914 @default.
• W1981990410 hasConceptScore W1981990410C171089720 @default.
• W1981990410 hasConceptScore W1981990410C184738001 @default.
• W1981990410 hasConceptScore W1981990410C2779317972 @default.
• W1981990410 hasConceptScore W1981990410C2780841215 @default.
• W1981990410 hasConceptScore W1981990410C38606739 @default.
• W1981990410 hasConceptScore W1981990410C59493245 @default.
• W1981990410 hasConceptScore W1981990410C71924100 @default.
• W1981990410 hasConceptScore W1981990410C86803240 @default.
• W1981990410 hasIssue "8" @default.
• W1981990410 hasLocation W19819904101 @default.
• W1981990410 hasLocation W19819904102 @default.
• W1981990410 hasLocation W19819904103 @default.
• W1981990410 hasLocation W19819904104 @default.
• W1981990410 hasOpenAccess W1981990410 @default.
• W1981990410 hasPrimaryLocation W19819904101 @default.
• W1981990410 hasRelatedWork W1578882671 @default.
• W1981990410 hasRelatedWork W1981540681 @default.
• W1981990410 hasRelatedWork W1991241272 @default.
• W1981990410 hasRelatedWork W2048445979 @default.

• next