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• W1981994454 abstract "Purpose of review Dendritic cells (DC) have become the focus of intense interest as regulators of immune responses, and it is now clear that DC maturation or function, or both, can be manipulated to promote their tolerogenicity, with potential for therapeutic application in bone marrow and organ transplantation. The purpose of this review is to survey recent insights and advances in basic and applied DC biology that provide the foundation for manipulation of the in vivo function of these important antigen-presenting cells (APCs) and for their ex vivo manipulation to promote transplantation tolerance. Recent findings This review highlights several important recent developments regarding (1) the generation and functional assessment of tolerogenic/regulatory DC; (2) the influence of immunosuppressive drugs on DC; (3) the properties of plasmacytoid DC, especially their immune regulatory function; (4) the impact of apoptotic cells and exosomes on DC function; (5) gene silencing in DC; (6) promotion of transplant tolerance by immature or alternatively activated DC; (7) preliminary studies in nonhuman primates; and (8) clinical observations on DC subsets in relation to transplant outcome. Summary Dendritic cell subsets in rodents and humans, including recently characterized plasmacytoid DC, have tolerogenic potential. Manipulation of DC development in the laboratory, using pharmacologic agents or cytokines or both, can render immature or alternatively activated DCs with capacity to promote organ transplant tolerance in rodents. At present these strategies can be envisaged in the clinic in relation to human live donor organ transplantation. Identification and characterization of tolerogenic or regulatory DC in clinically relevant, nonhuman primate models will allow testing of the most promising regimens in organ transplantation." @default.
• W1981994454 created "2016-06-24" @default.
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• W1981994454 date "2004-09-01" @default.
• W1981994454 modified "2023-10-12" @default.
• W1981994454 title "Manipulation of dendritic cells in organ transplantation: a major step towards graft tolerance?" @default.
• W1981994454 cites W1494759368 @default.
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• W1981994454 cites W1595217065 @default.
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• W1981994454 cites W1966848814 @default.
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• W1981994454 doi "https://doi.org/10.1097/01.mot.0000129652.57758.42" @default.
• W1981994454 hasPublicationYear "2004" @default.
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