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- W1982006759 abstract "AbstractTo explore the association of serum hyperhomocysteinaemia with 677C>T polymorphism in MTHFR gene among metformin-treated patients with type 2 diabetes. Serum-homocysteine levels of 227 diabetic subjects were measured before and after the metformin administration were analyzed statistically with respect to their genotype data for MTHFR 677C>T polymorphism. CC was the most prevalent genotype at MTHFR 677C>T in our sample and associated with the lowest homocysteine level. The patients with TT genotype had significantly elevated homocysteine compared with CC following metformin use (ORBaseline = 3.434 and 95% CI:0.622–4.127 vs. OREndpoint = 4.466 95% CI:3.124–5.53). A distinct statistical association between hyperhomocysteinaemia and the carriage of MTHFR 677C>T polymorphism was established among Indian diabetic patients who were treated with metformin. Our study underscores the importance of phamacogenetic analysis in diabetes-related therapeutics." @default.
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- W1982006759 date "2015-04-09" @default.
- W1982006759 modified "2023-10-14" @default.
- W1982006759 title "Association of MTHFR 677C>T genetic polymorphism with hyperhomocysteinemia in type 2 diabetes patients" @default.
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- W1982006759 doi "https://doi.org/10.1080/2331205x.2015.1017973" @default.
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