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- W198202208 abstract "In order to investigate the possible metabolic aromatic hydroxylation of the antihypertensive agent (S)-α-methyldopa, we have synthesized, resolved and established the absolute configuration of 6-hydroxy-α-methyldopa. With the aid of this compound, 6-hydroxy-α-methyldopamine, 6-hydroxy-α-methylnorepinephrine, and their corresponding deuterium labeled analogs, metabolic studies on brain tissues and urine samples obtained from drug treated rats have been carried out. Preliminary results on the hemodynamic effects of the (R)- and (S)-enantiomers of the title compound also are reported." @default.
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- W198202208 date "1979-01-01" @default.
- W198202208 modified "2023-09-27" @default.
- W198202208 title "STUDIES ON 2-METHYL-3-(2,4,5-TRIHYDROXYPHENYL)ALANINE, THE “6-HYDROXY ANALOG” OF α-METHYLDOPA" @default.
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- W198202208 doi "https://doi.org/10.1016/b978-1-4832-8363-0.50461-4" @default.
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