FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982022668> ?p ?o ?g. }

• W1982022668 endingPage "e41055" @default.
• W1982022668 startingPage "e41055" @default.
• W1982022668 abstract "Previous studies have reported that the tumour cells of nasopharyngeal carcinoma (NPC) exhibit recurrent chromosome abnormalities. These genetic changes are broadly assumed to lead to changes in gene expression which are important for the pathogenesis of this tumour. However, this assumption has yet to be formally tested at a global level. Therefore a genome wide analysis of chromosome copy number and gene expression was performed in tumour cells micro-dissected from the same NPC biopsies. Cellular tumour suppressor and tumour-promoting genes (TSG, TPG) and Epstein-Barr Virus (EBV)-encoded oncogenes were examined. The EBV-encoded genome maintenance protein EBNA1, along with the putative oncogenes LMP1, LMP2 and BARF1 were expressed in the majority of NPCs that were analysed. Significant downregulation of expression in an average of 76 cellular TSGs per tumour was found, whilst a per-tumour average of 88 significantly upregulated, TPGs occurred. The expression of around 60% of putative TPGs and TSGs was both up-and down-regulated in different types of cancer, suggesting that the simplistic classification of genes as TSGs or TPGs may not be entirely appropriate and that the concept of context-dependent onco-suppressors may be more extensive than previously recognised. No significant enrichment of TPGs within regions of frequent genomic gain was seen but TSGs were significantly enriched within regions of frequent genomic loss. It is suggested that loss of the FHIT gene may be a driver of NPC tumourigenesis. Notwithstanding the association of TSGs with regions of genomic loss, on a gene by gene basis and excepting homozygous deletions and high-level amplification, there is very little correlation between chromosomal copy number aberrations and expression levels of TSGs and TPGs in NPC." @default.
• W1982022668 created "2016-06-24" @default.
• W1982022668 creator A5003137991 @default.
• W1982022668 creator A5004694927 @default.
• W1982022668 creator A5012281019 @default.
• W1982022668 creator A5017842948 @default.
• W1982022668 creator A5024991309 @default.
• W1982022668 creator A5034656157 @default.
• W1982022668 creator A5034880731 @default.
• W1982022668 creator A5043258375 @default.
• W1982022668 creator A5063557693 @default.
• W1982022668 creator A5064347076 @default.
• W1982022668 creator A5066105795 @default.
• W1982022668 creator A5070258370 @default.
• W1982022668 creator A5071095797 @default.
• W1982022668 creator A5073555848 @default.
• W1982022668 creator A5073775367 @default.
• W1982022668 creator A5087374807 @default.
• W1982022668 creator A5088361499 @default.
• W1982022668 date "2012-07-17" @default.
• W1982022668 modified "2023-10-06" @default.
• W1982022668 title "A Global View of the Oncogenic Landscape in Nasopharyngeal Carcinoma: An Integrated Analysis at the Genetic and Expression Levels" @default.
• W1982022668 cites W1966880393 @default.
• W1982022668 cites W1982874627 @default.
• W1982022668 cites W1993881461 @default.
• W1982022668 cites W1997733964 @default.
• W1982022668 cites W2000603439 @default.
• W1982022668 cites W2009327119 @default.
• W1982022668 cites W2009725516 @default.
• W1982022668 cites W2026177356 @default.
• W1982022668 cites W2034336979 @default.
• W1982022668 cites W2038437697 @default.
• W1982022668 cites W2048295632 @default.
• W1982022668 cites W2048389796 @default.
• W1982022668 cites W2055423089 @default.
• W1982022668 cites W2057945544 @default.
• W1982022668 cites W2065594827 @default.
• W1982022668 cites W2071409339 @default.
• W1982022668 cites W2071538807 @default.
• W1982022668 cites W2075596154 @default.
• W1982022668 cites W2075796873 @default.
• W1982022668 cites W2078069292 @default.
• W1982022668 cites W2078689382 @default.
• W1982022668 cites W2079614925 @default.
• W1982022668 cites W2081011809 @default.
• W1982022668 cites W2088561852 @default.
• W1982022668 cites W2092858757 @default.
• W1982022668 cites W2096083625 @default.
• W1982022668 cites W2102545578 @default.
• W1982022668 cites W2111247797 @default.
• W1982022668 cites W2115591535 @default.
• W1982022668 cites W2116575638 @default.
• W1982022668 cites W2118411662 @default.
• W1982022668 cites W2134672574 @default.
• W1982022668 cites W2136280424 @default.
• W1982022668 cites W2138350553 @default.
• W1982022668 cites W2139889421 @default.
• W1982022668 cites W2148067805 @default.
• W1982022668 cites W2153892308 @default.
• W1982022668 cites W2155142728 @default.
• W1982022668 cites W2163324118 @default.
• W1982022668 cites W2168621651 @default.
• W1982022668 cites W4297833063 @default.
• W1982022668 doi "https://doi.org/10.1371/journal.pone.0041055" @default.
• W1982022668 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3398876" @default.
• W1982022668 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22815911" @default.
• W1982022668 hasPublicationYear "2012" @default.
• W1982022668 type Work @default.
• W1982022668 sameAs 1982022668 @default.
• W1982022668 citedByCount "45" @default.
• W1982022668 countsByYear W19820226682013 @default.
• W1982022668 countsByYear W19820226682014 @default.
• W1982022668 countsByYear W19820226682015 @default.
• W1982022668 countsByYear W19820226682016 @default.
• W1982022668 countsByYear W19820226682017 @default.
• W1982022668 countsByYear W19820226682018 @default.
• W1982022668 countsByYear W19820226682019 @default.
• W1982022668 countsByYear W19820226682020 @default.
• W1982022668 countsByYear W19820226682021 @default.
• W1982022668 countsByYear W19820226682022 @default.
• W1982022668 countsByYear W19820226682023 @default.
• W1982022668 crossrefType "journal-article" @default.
• W1982022668 hasAuthorship W1982022668A5003137991 @default.
• W1982022668 hasAuthorship W1982022668A5004694927 @default.
• W1982022668 hasAuthorship W1982022668A5012281019 @default.
• W1982022668 hasAuthorship W1982022668A5017842948 @default.
• W1982022668 hasAuthorship W1982022668A5024991309 @default.
• W1982022668 hasAuthorship W1982022668A5034656157 @default.
• W1982022668 hasAuthorship W1982022668A5034880731 @default.
• W1982022668 hasAuthorship W1982022668A5043258375 @default.
• W1982022668 hasAuthorship W1982022668A5063557693 @default.
• W1982022668 hasAuthorship W1982022668A5064347076 @default.
• W1982022668 hasAuthorship W1982022668A5066105795 @default.
• W1982022668 hasAuthorship W1982022668A5070258370 @default.
• W1982022668 hasAuthorship W1982022668A5071095797 @default.
• W1982022668 hasAuthorship W1982022668A5073555848 @default.
• W1982022668 hasAuthorship W1982022668A5073775367 @default.
• W1982022668 hasAuthorship W1982022668A5087374807 @default.

• next