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• W1982024384 abstract "The term “Interstitial cells of Cajal” (ICC) encompass several groups of mesenchymal cells present along the gastro-intestinal (GI) tract, in close association with smooth muscle cells and elements of the enteric nervous system (ENS). Transmission electron microscopy (TEM) has been for many years the only reliable tool to study ICC. Whilst TEM remains the golden standard for identification of ICC, the observation that the receptor tyrosine kinase KIT is an ICC marker and plays a key role in their development (1) has been instrumental for numerous immunohistochemical studies over the last decennia and for the soaring interest for these cells in the interstitium of the smooth muscle layers of the GI tract. ICC form extensive networks of electrically coupled cells. Defined groups of ICC are the source of the spontaneous slow waves of depolarization (pacemaker component) recorded in the GI muscularis propria (2) whereas other ICC appear to be involved in neurotransmission (3). The abundant literature dealing with the ultrastructure, light microscopy morphology, functions and development of ICC and of the neighboring fibroblast-like cells (FLC), have been critically reviewed recently (4). Abnormal distribution of ICC has already been reported in several human diseases and abnormal function of ICC might actually be involved in a variety of disorders of GI transit. This lecture will address: the basic morphology and relationships of ICC along the GI tract, mainly based on data from immunohistochemistry and confocal microscopy in man and mouse; the alteration of ICC distribution reported in several human GI diseases, with emphasis on pediatric conditions, e.g. achalasia of the cardia in Allgrove's syndrome (5), infantile hypertrophic pyloric stenosis (6), Hirschsprung's disease (7), transient neonatal intestinal pseudoobstruction (8); the emerging place for interstitial cells (ICC and FLC) in our understanding of the neuromuscular control of GI motility. Whereas substantial advances have been booked in recent years on a number of basic aspects, GI transit problems remain challenging for the clinicians. Translational science (9) thus opens exciting perspectives for innovative approaches of GI dysmotility." @default.
• W1982024384 created "2016-06-24" @default.
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• W1982024384 date "2005-09-01" @default.
• W1982024384 modified "2023-10-18" @default.
• W1982024384 title "Clinical Disorders Related to ICCs" @default.
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• W1982024384 doi "https://doi.org/10.1097/01.scs.0000180309.09676.87" @default.
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