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• W1982024897 abstract "Simple synthesis of modafinil derivatives and their biological activity are described. The key synthetic strategies involve substitution and coupling reactions. We determined the anti-inflammatory effects of modafinil derivatives in cultured BV2 cells by measuring the inhibition of nitrite production and expression of iNOS and COX-2 after LPS stimulation. It was found that for sulfide analogues introduction of aliphatic groups on the amide part (compounds 11a–d) resulted in lower anti-inflammatory activity compared with cyclic or aromatic moieties (compounds 11e–k). However, for the sulfoxide analogues, introduction of aliphatic moieties (compounds 12a–d) showed higher anti-inflammatory activity than cyclic or aromatic fragments (compounds 12e–k) in BV-2 microglia cells." @default.
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• W1982024897 date "2012-09-03" @default.
• W1982024897 modified "2023-10-18" @default.
• W1982024897 title "Simple Synthesis of Modafinil Derivatives and Their Anti-inflammatory Activity" @default.
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• W1982024897 doi "https://doi.org/10.3390/molecules170910446" @default.
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