Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982034802> ?p ?o ?g. }
- W1982034802 abstract "We have previously described the creation and analysis of a Notch1 activity-trap mouse line, Notch1 intramembrane proteolysis-Cre6MT or N1IP::CreLO, that marked cells experiencing relatively high levels of Notch1 activation. Here, we report and characterize a second line with improved sensitivity (N1IP::CreHI) to mark cells experiencing lower levels of Notch1 activation. This improvement was achieved by increasing transcript stability and by restoring the native carboxy terminus of Cre, resulting in a five- to tenfold increase in Cre activity. The magnitude of this effect probably impacts Cre activity in strains with carboxy-terminal Ert2 fusion. These two trap lines and the related line N1IP::CreERT2 form a complementary mapping tool kit to identify changes in Notch1 activation patterns in vivo as the consequence of genetic or pharmaceutical intervention, and illustrate the variation in Notch1 signal strength from one tissue to the next and across developmental time." @default.
- W1982034802 created "2016-06-24" @default.
- W1982034802 creator A5000322280 @default.
- W1982034802 creator A5016232259 @default.
- W1982034802 creator A5040517835 @default.
- W1982034802 creator A5047100787 @default.
- W1982034802 creator A5063310059 @default.
- W1982034802 creator A5077148194 @default.
- W1982034802 creator A5078024000 @default.
- W1982034802 creator A5084882105 @default.
- W1982034802 date "2015-01-01" @default.
- W1982034802 modified "2023-10-01" @default.
- W1982034802 title "Second-generation Notch1 activity-trap mouse line (N1IP::CreHI) provides a more comprehensive map of cells experiencing Notch1 activity" @default.
- W1982034802 cites W1504123405 @default.
- W1982034802 cites W1527775890 @default.
- W1982034802 cites W1542949307 @default.
- W1982034802 cites W1568731054 @default.
- W1982034802 cites W1590546489 @default.
- W1982034802 cites W1691160266 @default.
- W1982034802 cites W1768274470 @default.
- W1982034802 cites W1856143987 @default.
- W1982034802 cites W1893910909 @default.
- W1982034802 cites W1963506245 @default.
- W1982034802 cites W1965132716 @default.
- W1982034802 cites W1969335165 @default.
- W1982034802 cites W1969414295 @default.
- W1982034802 cites W1970669095 @default.
- W1982034802 cites W1973300558 @default.
- W1982034802 cites W1977253322 @default.
- W1982034802 cites W1984475127 @default.
- W1982034802 cites W1985191536 @default.
- W1982034802 cites W1985375469 @default.
- W1982034802 cites W1993913999 @default.
- W1982034802 cites W1997801717 @default.
- W1982034802 cites W2002307675 @default.
- W1982034802 cites W2002647529 @default.
- W1982034802 cites W2021302907 @default.
- W1982034802 cites W2027060853 @default.
- W1982034802 cites W2029969016 @default.
- W1982034802 cites W2035382892 @default.
- W1982034802 cites W2038193334 @default.
- W1982034802 cites W2040381240 @default.
- W1982034802 cites W2040461956 @default.
- W1982034802 cites W2042163600 @default.
- W1982034802 cites W2045236309 @default.
- W1982034802 cites W2049756111 @default.
- W1982034802 cites W2052158351 @default.
- W1982034802 cites W2054521968 @default.
- W1982034802 cites W2057383724 @default.
- W1982034802 cites W2062663137 @default.
- W1982034802 cites W2065569210 @default.
- W1982034802 cites W2066621486 @default.
- W1982034802 cites W2072966096 @default.
- W1982034802 cites W2079541044 @default.
- W1982034802 cites W2088925327 @default.
- W1982034802 cites W2095390522 @default.
- W1982034802 cites W2097845265 @default.
- W1982034802 cites W2098503611 @default.
- W1982034802 cites W2099770647 @default.
- W1982034802 cites W2100699398 @default.
- W1982034802 cites W2101735178 @default.
- W1982034802 cites W2104135721 @default.
- W1982034802 cites W2109627278 @default.
- W1982034802 cites W2118589362 @default.
- W1982034802 cites W2128295200 @default.
- W1982034802 cites W2131517747 @default.
- W1982034802 cites W2134306237 @default.
- W1982034802 cites W2134599949 @default.
- W1982034802 cites W2134794571 @default.
- W1982034802 cites W2142869215 @default.
- W1982034802 cites W2145967409 @default.
- W1982034802 cites W2146150145 @default.
- W1982034802 cites W2148599148 @default.
- W1982034802 cites W2150013759 @default.
- W1982034802 cites W2153836282 @default.
- W1982034802 cites W2154861644 @default.
- W1982034802 cites W2155066685 @default.
- W1982034802 cites W2157288494 @default.
- W1982034802 cites W2171623512 @default.
- W1982034802 doi "https://doi.org/10.1242/dev.119529" @default.
- W1982034802 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4360173" @default.
- W1982034802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25725069" @default.
- W1982034802 hasPublicationYear "2015" @default.
- W1982034802 type Work @default.
- W1982034802 sameAs 1982034802 @default.
- W1982034802 citedByCount "19" @default.
- W1982034802 countsByYear W19820348022015 @default.
- W1982034802 countsByYear W19820348022016 @default.
- W1982034802 countsByYear W19820348022017 @default.
- W1982034802 countsByYear W19820348022018 @default.
- W1982034802 countsByYear W19820348022019 @default.
- W1982034802 countsByYear W19820348022020 @default.
- W1982034802 countsByYear W19820348022021 @default.
- W1982034802 countsByYear W19820348022022 @default.
- W1982034802 countsByYear W19820348022023 @default.
- W1982034802 crossrefType "journal-article" @default.
- W1982034802 hasAuthorship W1982034802A5000322280 @default.
- W1982034802 hasAuthorship W1982034802A5016232259 @default.
- W1982034802 hasAuthorship W1982034802A5040517835 @default.
- W1982034802 hasAuthorship W1982034802A5047100787 @default.