FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982034861> ?p ?o ?g. }

• W1982034861 endingPage "303" @default.
• W1982034861 startingPage "297" @default.
• W1982034861 abstract "The physiological role of melanin-concentrating hormone (MCH) in mammals is still very elusive, but this peptide might participate in the central control of the hypothalamopituitary adrenal (HPA) axis during adaptation to stress. Cloning and sequencing of the rat MCH (rMCH) cDNA revealed the existence of additional peptides encoded into the MCH precursor. Among these peptides, neuropeptide (N) glutamic acid (E) isoleucine (I) arnide (NEI) is co-processed and secreted with MCH in rat hypothalamus. In the present work we examined: (1) The pattern of rMCH mRNA expression during the light and dark conditions in the rat hypothalamus and (2) The effect of intracerebroventricular (ICV) injections of rMCH and NEI in the control of basal or ether stress-modified release of corticotropin (ACTH), prolactin (PRL) and growth hormone (GH) secretion in vivo in light-on and light-off conditions. Our data indicate that rMCH mRNA levels do not change during the light-on period, but increase after the onset of darkness. Either alone or co-administered, rMCH and NEI do not modify basal secretion of GH and PRL at any time tested nor do they alter ether stress-induced changes in these two hormonal secretions. At the end of the light on period corresponding to the peak of the circadian rhythm in ACTH, administration of rMCH but not NEI leads to a decrease in ACTH levels while MCH is not effective during the light off period of the cycle (i.e. when basal ACTH levels are already low). Using a moderate ether induced stress, ACTH levels are only stimulated during the dark phase of the cycle. rMCH (63 or 210 nmoles) prevents the rise in ACTH release while NEI alone does not modify the stress response. Co-administration of both peptides before stress results in an abolition of the rMCH induced inhibition of ACTH plasma levels. Taken together, these data indicate that rMCH may act as a central corticotropin inhibitory factor involved in the circadian rhythmicity of plasma ACTH levels and that NEI antagonizes its action." @default.
• W1982034861 created "2016-06-24" @default.
• W1982034861 creator A5029591592 @default.
• W1982034861 creator A5066500398 @default.
• W1982034861 creator A5077163477 @default.
• W1982034861 creator A5078180070 @default.
• W1982034861 creator A5079811614 @default.
• W1982034861 creator A5089319211 @default.
• W1982034861 creator A5089989719 @default.
• W1982034861 date "1995-04-01" @default.
• W1982034861 modified "2023-10-17" @default.
• W1982034861 title "Neuropeptide-E-1 Antagonizes the Action of Melanin-Concentrating Hormone on Stress-Induced Release of Adrenocorticotropin in the Rat" @default.
• W1982034861 cites W1964214345 @default.
• W1982034861 cites W1973373610 @default.
• W1982034861 cites W1978082185 @default.
• W1982034861 cites W1986845109 @default.
• W1982034861 cites W1991256932 @default.
• W1982034861 cites W2004917303 @default.
• W1982034861 cites W2005344985 @default.
• W1982034861 cites W2009712927 @default.
• W1982034861 cites W2024428069 @default.
• W1982034861 cites W2025381000 @default.
• W1982034861 cites W2035705440 @default.
• W1982034861 cites W2046265271 @default.
• W1982034861 cites W2047187902 @default.
• W1982034861 cites W2049641826 @default.
• W1982034861 cites W2058106399 @default.
• W1982034861 cites W2066503167 @default.
• W1982034861 cites W2067039618 @default.
• W1982034861 cites W2068730553 @default.
• W1982034861 cites W2069982017 @default.
• W1982034861 cites W2073148375 @default.
• W1982034861 cites W2078632969 @default.
• W1982034861 cites W2094259909 @default.
• W1982034861 cites W2134812217 @default.
• W1982034861 cites W2139453773 @default.
• W1982034861 cites W2254356987 @default.
• W1982034861 cites W2506567205 @default.
• W1982034861 cites W4230878184 @default.
• W1982034861 cites W4237212669 @default.
• W1982034861 cites W4254999964 @default.
• W1982034861 cites W4255304519 @default.
• W1982034861 cites W4256605812 @default.
• W1982034861 cites W963227066 @default.
• W1982034861 doi "https://doi.org/10.1111/j.1365-2826.1995.tb00761.x" @default.
• W1982034861 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7647772" @default.
• W1982034861 hasPublicationYear "1995" @default.
• W1982034861 type Work @default.
• W1982034861 sameAs 1982034861 @default.
• W1982034861 citedByCount "82" @default.
• W1982034861 countsByYear W19820348612014 @default.
• W1982034861 countsByYear W19820348612015 @default.
• W1982034861 countsByYear W19820348612017 @default.
• W1982034861 countsByYear W19820348612018 @default.
• W1982034861 countsByYear W19820348612019 @default.
• W1982034861 countsByYear W19820348612021 @default.
• W1982034861 countsByYear W19820348612022 @default.
• W1982034861 crossrefType "journal-article" @default.
• W1982034861 hasAuthorship W1982034861A5029591592 @default.
• W1982034861 hasAuthorship W1982034861A5066500398 @default.
• W1982034861 hasAuthorship W1982034861A5077163477 @default.
• W1982034861 hasAuthorship W1982034861A5078180070 @default.
• W1982034861 hasAuthorship W1982034861A5079811614 @default.
• W1982034861 hasAuthorship W1982034861A5089319211 @default.
• W1982034861 hasAuthorship W1982034861A5089989719 @default.
• W1982034861 hasConcept C118303440 @default.
• W1982034861 hasConcept C126322002 @default.
• W1982034861 hasConcept C134018914 @default.
• W1982034861 hasConcept C170493617 @default.
• W1982034861 hasConcept C185592680 @default.
• W1982034861 hasConcept C2776632733 @default.
• W1982034861 hasConcept C2777003273 @default.
• W1982034861 hasConcept C2778024521 @default.
• W1982034861 hasConcept C2779064019 @default.
• W1982034861 hasConcept C2779306644 @default.
• W1982034861 hasConcept C2780352252 @default.
• W1982034861 hasConcept C49039625 @default.
• W1982034861 hasConcept C71315377 @default.
• W1982034861 hasConcept C71924100 @default.
• W1982034861 hasConcept C86803240 @default.
• W1982034861 hasConceptScore W1982034861C118303440 @default.
• W1982034861 hasConceptScore W1982034861C126322002 @default.
• W1982034861 hasConceptScore W1982034861C134018914 @default.
• W1982034861 hasConceptScore W1982034861C170493617 @default.
• W1982034861 hasConceptScore W1982034861C185592680 @default.
• W1982034861 hasConceptScore W1982034861C2776632733 @default.
• W1982034861 hasConceptScore W1982034861C2777003273 @default.
• W1982034861 hasConceptScore W1982034861C2778024521 @default.
• W1982034861 hasConceptScore W1982034861C2779064019 @default.
• W1982034861 hasConceptScore W1982034861C2779306644 @default.
• W1982034861 hasConceptScore W1982034861C2780352252 @default.
• W1982034861 hasConceptScore W1982034861C49039625 @default.
• W1982034861 hasConceptScore W1982034861C71315377 @default.
• W1982034861 hasConceptScore W1982034861C71924100 @default.
• W1982034861 hasConceptScore W1982034861C86803240 @default.
• W1982034861 hasIssue "4" @default.
• W1982034861 hasLocation W19820348611 @default.
• W1982034861 hasLocation W19820348612 @default.

• next