FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982039056> ?p ?o ?g. }

• W1982039056 endingPage "e413" @default.
• W1982039056 startingPage "e413" @default.
• W1982039056 abstract "Blocks in genetic programs required for terminal myeloid differentiation and aberrant proliferation characterize acute myeloid leukemia (AML) cells. 1,25-Dihydroxy-vitamin D3 (VitD3) arrests proliferation of AML cells and induces their differentiation into mature monocytes. In a previous study, we showed that miR-26a was induced upon VitD3-mediated monocytic differentiation. Here, we identify E2F7 as a novel target of miR-26a. We show that E2F7 significantly promotes cell cycle progression and inhibits monocytic differentiation of AML cells. We also demonstrate that E2F7 binds the cyclin-dependent kinase inhibitor p21CIP1/WAF1 (cyclin-dependent kinase inhibitor 1A) promoter repressing its expression. Moreover, interfering with E2F7 expression results in inhibition of c-Myc (v-myc myelocytomatosis viral oncogene homolog) transcriptional activity. This leads to the downregulation of c-Myc transcriptional target miR-17-92 cluster, whose expression has a well-defined role in contributing to block monocytic differentiation and sustain AML cell proliferation. Finally, we show that the expression of E2F7 is upregulated in primary blasts from AML patients. Thus, these findings indicate that the newly identified miR-26a target E2F7 might have an important role in monocytic differentiation and leukemogenesis." @default.
• W1982039056 created "2016-06-24" @default.
• W1982039056 creator A5000156462 @default.
• W1982039056 creator A5008824754 @default.
• W1982039056 creator A5015570184 @default.
• W1982039056 creator A5027602447 @default.
• W1982039056 creator A5035886740 @default.
• W1982039056 creator A5041181079 @default.
• W1982039056 creator A5049391009 @default.
• W1982039056 creator A5060801549 @default.
• W1982039056 creator A5071089132 @default.
• W1982039056 creator A5084642413 @default.
• W1982039056 date "2012-10-25" @default.
• W1982039056 modified "2023-10-06" @default.
• W1982039056 title "The microRNA-26a target E2F7 sustains cell proliferation and inhibits monocytic differentiation of acute myeloid leukemia cells" @default.
• W1982039056 cites W1804959557 @default.
• W1982039056 cites W1885235228 @default.
• W1982039056 cites W1925932947 @default.
• W1982039056 cites W1966176361 @default.
• W1982039056 cites W2007978249 @default.
• W1982039056 cites W2015003540 @default.
• W1982039056 cites W2018599516 @default.
• W1982039056 cites W2020288787 @default.
• W1982039056 cites W2031913409 @default.
• W1982039056 cites W2033581856 @default.
• W1982039056 cites W2036561487 @default.
• W1982039056 cites W2038796494 @default.
• W1982039056 cites W2050249118 @default.
• W1982039056 cites W2050850788 @default.
• W1982039056 cites W2051342289 @default.
• W1982039056 cites W2059533214 @default.
• W1982039056 cites W2062625397 @default.
• W1982039056 cites W2069182922 @default.
• W1982039056 cites W2076067574 @default.
• W1982039056 cites W2077068179 @default.
• W1982039056 cites W2077916974 @default.
• W1982039056 cites W2083255319 @default.
• W1982039056 cites W2092793317 @default.
• W1982039056 cites W2094915354 @default.
• W1982039056 cites W2100975741 @default.
• W1982039056 cites W2102423175 @default.
• W1982039056 cites W2105613536 @default.
• W1982039056 cites W2123408027 @default.
• W1982039056 cites W2123894642 @default.
• W1982039056 cites W2131964760 @default.
• W1982039056 cites W2134597949 @default.
• W1982039056 cites W2138366746 @default.
• W1982039056 cites W2140037284 @default.
• W1982039056 cites W2144965236 @default.
• W1982039056 cites W2148276874 @default.
• W1982039056 cites W2158216140 @default.
• W1982039056 cites W2159807040 @default.
• W1982039056 cites W2162741492 @default.
• W1982039056 cites W2163229196 @default.
• W1982039056 cites W2330718429 @default.
• W1982039056 doi "https://doi.org/10.1038/cddis.2012.151" @default.
• W1982039056 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3481138" @default.
• W1982039056 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23096114" @default.
• W1982039056 hasPublicationYear "2012" @default.
• W1982039056 type Work @default.
• W1982039056 sameAs 1982039056 @default.
• W1982039056 citedByCount "62" @default.
• W1982039056 countsByYear W19820390562013 @default.
• W1982039056 countsByYear W19820390562014 @default.
• W1982039056 countsByYear W19820390562015 @default.
• W1982039056 countsByYear W19820390562016 @default.
• W1982039056 countsByYear W19820390562017 @default.
• W1982039056 countsByYear W19820390562018 @default.
• W1982039056 countsByYear W19820390562019 @default.
• W1982039056 countsByYear W19820390562020 @default.
• W1982039056 countsByYear W19820390562021 @default.
• W1982039056 countsByYear W19820390562022 @default.
• W1982039056 countsByYear W19820390562023 @default.
• W1982039056 crossrefType "journal-article" @default.
• W1982039056 hasAuthorship W1982039056A5000156462 @default.
• W1982039056 hasAuthorship W1982039056A5008824754 @default.
• W1982039056 hasAuthorship W1982039056A5015570184 @default.
• W1982039056 hasAuthorship W1982039056A5027602447 @default.
• W1982039056 hasAuthorship W1982039056A5035886740 @default.
• W1982039056 hasAuthorship W1982039056A5041181079 @default.
• W1982039056 hasAuthorship W1982039056A5049391009 @default.
• W1982039056 hasAuthorship W1982039056A5060801549 @default.
• W1982039056 hasAuthorship W1982039056A5071089132 @default.
• W1982039056 hasAuthorship W1982039056A5084642413 @default.
• W1982039056 hasBestOaLocation W19820390561 @default.
• W1982039056 hasConcept C104317684 @default.
• W1982039056 hasConcept C127561419 @default.
• W1982039056 hasConcept C145059251 @default.
• W1982039056 hasConcept C148738053 @default.
• W1982039056 hasConcept C1491633281 @default.
• W1982039056 hasConcept C2776601000 @default.
• W1982039056 hasConcept C2778729363 @default.
• W1982039056 hasConcept C2779282312 @default.
• W1982039056 hasConcept C2779982571 @default.
• W1982039056 hasConcept C2781018059 @default.
• W1982039056 hasConcept C2781121885 @default.
• W1982039056 hasConcept C29537977 @default.
• W1982039056 hasConcept C502942594 @default.

• next