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• W1982047105 abstract "Previous small-molecule antiangiogenics have compromised chemotherapy dose intensity in breast cancer. We present a phase I trial of a novel selective agent, nintedanib, plus standard chemotherapy in early breast cancer. Her-2-negative breast cancer patients with tumours larger than 2 cm were eligible for dose-escalation trial (classic 3+3 method). The recommended phase II dose (RP2D) was 150 mg BID of nintedanib combined with standard dose of weekly paclitaxel followed by adriamycin plus cyclophosphamide. The dose-limiting toxicity was transaminase elevation. At the RP2D, the dose intensity was ∼100%. The pathologic complete response was 50%. The combination allows the delivery of full-dose intensity, while efficacy seems promising." @default.
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• W1982047105 date "2014-07-24" @default.
• W1982047105 modified "2023-10-18" @default.
• W1982047105 title "Phase I clinical trial of nintedanib plus paclitaxel in early HER-2-negative breast cancer (CNIO-BR-01-2010/GEICAM-2010-10 study)" @default.
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• W1982047105 doi "https://doi.org/10.1038/bjc.2014.397" @default.
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