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• W1982049677 endingPage "12260" @default.
• W1982049677 startingPage "12254" @default.
• W1982049677 abstract "The insulin-like growth factor I receptor (IGF-IR) controls the extent of cell proliferation in a variety of cell types by at least 3 different ways: it is mitogenic, it causes transformation, and it protects cells from apoptosis. Previous reports indicated that certain domains in the C terminus of the IGF-IR transmitted a transforming signal that is additional to and separate from the mitogenic signal. We have now mutated the four serine residues at 1280-1283 of the IGF-IR, and transfected the mutant receptor into R− cells. Cells expressing the mutant receptor are fully responsive to IGF-I-mediated mitogenesis, but are not transformed (no colony formation in soft agar). Several downstream signal transducers are not affected by the mutation, again suggesting a separate pathway for transformation. The mutant receptor can act as a dominant negative for growth, but cannot induce apoptosis in cells with endogenous wild-type receptors. The insulin-like growth factor I receptor (IGF-IR) controls the extent of cell proliferation in a variety of cell types by at least 3 different ways: it is mitogenic, it causes transformation, and it protects cells from apoptosis. Previous reports indicated that certain domains in the C terminus of the IGF-IR transmitted a transforming signal that is additional to and separate from the mitogenic signal. We have now mutated the four serine residues at 1280-1283 of the IGF-IR, and transfected the mutant receptor into R− cells. Cells expressing the mutant receptor are fully responsive to IGF-I-mediated mitogenesis, but are not transformed (no colony formation in soft agar). Several downstream signal transducers are not affected by the mutation, again suggesting a separate pathway for transformation. The mutant receptor can act as a dominant negative for growth, but cannot induce apoptosis in cells with endogenous wild-type receptors." @default.
• W1982049677 created "2016-06-24" @default.
• W1982049677 creator A5019691586 @default.
• W1982049677 creator A5086267331 @default.
• W1982049677 creator A5087771423 @default.
• W1982049677 date "1996-05-01" @default.
• W1982049677 modified "2023-10-15" @default.
• W1982049677 title "Effect of Mutations at Serines 1280–1283 on the Mitogenic and Transforming Activities of the Insulin-like Growth Factor I Receptor" @default.
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• W1982049677 doi "https://doi.org/10.1074/jbc.271.21.12254" @default.
• W1982049677 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8647823" @default.
• W1982049677 hasPublicationYear "1996" @default.
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