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• W1982051575 abstract "ABSTRACT Recent studies have established a protective role for T cells during primary West Nile virus (WNV) infection. Binding of CD40 by CD40 ligand (CD40L) on activated CD4 + T cells provides an important costimulatory signal for immunoglobulin class switching, antibody affinity maturation, and priming of CD8 + T-cell responses. We examined here the function of CD40-dependent interactions in limiting primary WNV infection. Compared to congenic wild-type mice, CD40 −/− mice uniformly succumbed to WNV infection. Although CD40 −/− mice produced low levels of WNV-specific immunoglobulin M (IgM) and IgG, viral clearance from the spleen and serum was not altered, and CD8 + T-cell priming in peripheral lymphoid tissues was normal. Unexpectedly, CD8 + T-cell trafficking to the central nervous system (CNS) was markedly impaired in CD40 −/− mice, and this correlated with elevated WNV titers in the CNS and death. In the brains of CD40 −/− mice, T cells were retained in the perivascular space and did not migrate into the parenchyma, the predominant site of WNV infection. In contrast, in wild-type mice, T cells trafficked to the site of infection in neurons. Beside its role in maturation of antibody responses, our experiments suggest a novel function of CD40-CD40L interactions: to facilitate T-cell migration across the blood-brain barrier to control WNV infection." @default.
• W1982051575 created "2016-06-24" @default.
• W1982051575 creator A5003745974 @default.
• W1982051575 creator A5016005915 @default.
• W1982051575 creator A5046722897 @default.
• W1982051575 creator A5087839631 @default.
• W1982051575 date "2007-09-15" @default.
• W1982051575 modified "2023-10-16" @default.
• W1982051575 title "CD40-CD40 Ligand Interactions Promote Trafficking of CD8 ⁺ T Cells into the Brain and Protection against West Nile Virus Encephalitis" @default.
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• W1982051575 doi "https://doi.org/10.1128/jvi.00941-07" @default.
• W1982051575 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2045405" @default.
• W1982051575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17626103" @default.
• W1982051575 hasPublicationYear "2007" @default.
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