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- W1982057114 abstract "The neural cell adhesion molecule (NCAM) is a calcium-independent cell adhesion molecule that operates through a homophilic binding mechanism and is an important mediator of cell-cell interactions in a number of tissues including brain and skeletal muscle. The NCAM gene has been isolated and mechanisms for generating different NCAM proteins described. Alternative splicing allows the generation of more than twenty NCAM isoforms. In addition specific N- and O-linked carbohydrate modifications are likely to modulate NCAM function. Strategies are being developed to assess the role of NCAM isoforms and post-translational modifications by using gene transfer methods in conjunction with model assay systems. In this context, we will discuss the effects of polysialylation and alternative splicing on the ability of NCAM to function as a molecule that promotes neurite outgrowth." @default.
- W1982057114 created "2016-06-24" @default.
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- W1982057114 date "1991-08-01" @default.
- W1982057114 modified "2023-09-28" @default.
- W1982057114 title "Structure and function of the gene for neural cell adhesion molecule" @default.
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- W1982057114 doi "https://doi.org/10.1016/1044-5765(91)90045-p" @default.
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