FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982061234> ?p ?o ?g. }

• W1982061234 endingPage "1623.e5" @default.
• W1982061234 startingPage "1612" @default.
• W1982061234 abstract "Previous studies have indicated that a defective epithelial barrier leads to inflammation of the underlying lamina propria. Nevertheless, it is likely that physiologic breaks in the barrier must occur for homeostatic regulatory T cells to develop. We determined the effect of agents that disrupt epithelial tight junctions (ethanol and AT1002, a Vibrio cholerae zonula occludens toxin hexapeptide) on regulatory T-cell induction and resistance to induction of colitis by trinitrobenzene sulfonic acid (TNBS).The effects of ethanol and AT1002 on colon immune function were evaluated by their capacity to induce direct phenotypic or functional changes in effector and regulatory cell populations and their indirect effect on the development of TNBS-induced colitis. The basis of regulatory cell development was evaluated with in vitro studies of isolated dendritic cell populations. The role of innate immunity was evaluated by in vivo gene silencing studies utilizing Toll-like receptor (TLR)-2-specific small interfering RNA (siRNA).Both ethanol and AT1002 induced persistent latency-associated peptide-positive CD4(+) regulatory T cells that, as shown in adoptive transfer studies, render mice resistant to the induction of TNBS colitis. The development of these cells requires the presence of an intact microflora and the activity of CD11c(+) dendritic cells. Their induction is also influenced by innate immune factors operating through TLR-2, because attenuation of TLR-2 signaling by in vivo TLR-2 siRNA administration prevents their development.A mild and/or transient breach in epithelial barrier function leads to dominant regulatory T-cell responses that protect the mucosa from inflammation." @default.
• W1982061234 created "2016-06-24" @default.
• W1982061234 creator A5000030352 @default.
• W1982061234 creator A5005121596 @default.
• W1982061234 creator A5009414735 @default.
• W1982061234 creator A5051210772 @default.
• W1982061234 creator A5053370481 @default.
• W1982061234 creator A5056842523 @default.
• W1982061234 creator A5069892594 @default.
• W1982061234 creator A5074404662 @default.
• W1982061234 creator A5077194201 @default.
• W1982061234 creator A5083001869 @default.
• W1982061234 date "2008-11-01" @default.
• W1982061234 modified "2023-10-03" @default.
• W1982061234 title "A Transient Breach in the Epithelial Barrier Leads to Regulatory T-Cell Generation and Resistance to Experimental Colitis" @default.
• W1982061234 cites W1553269519 @default.
• W1982061234 cites W1601070312 @default.
• W1982061234 cites W1642204422 @default.
• W1982061234 cites W2002128729 @default.
• W1982061234 cites W2007762873 @default.
• W1982061234 cites W2022213145 @default.
• W1982061234 cites W2027586189 @default.
• W1982061234 cites W2037259928 @default.
• W1982061234 cites W2049449911 @default.
• W1982061234 cites W2070413937 @default.
• W1982061234 cites W2074006404 @default.
• W1982061234 cites W2075702769 @default.
• W1982061234 cites W2083089709 @default.
• W1982061234 cites W2115207445 @default.
• W1982061234 cites W2153509933 @default.
• W1982061234 cites W2160670021 @default.
• W1982061234 cites W2171980652 @default.
• W1982061234 doi "https://doi.org/10.1053/j.gastro.2008.07.028" @default.
• W1982061234 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18765239" @default.
• W1982061234 hasPublicationYear "2008" @default.
• W1982061234 type Work @default.
• W1982061234 sameAs 1982061234 @default.
• W1982061234 citedByCount "78" @default.
• W1982061234 countsByYear W19820612342012 @default.
• W1982061234 countsByYear W19820612342013 @default.
• W1982061234 countsByYear W19820612342014 @default.
• W1982061234 countsByYear W19820612342015 @default.
• W1982061234 countsByYear W19820612342016 @default.
• W1982061234 countsByYear W19820612342017 @default.
• W1982061234 countsByYear W19820612342018 @default.
• W1982061234 countsByYear W19820612342019 @default.
• W1982061234 countsByYear W19820612342020 @default.
• W1982061234 countsByYear W19820612342021 @default.
• W1982061234 countsByYear W19820612342022 @default.
• W1982061234 countsByYear W19820612342023 @default.
• W1982061234 crossrefType "journal-article" @default.
• W1982061234 hasAuthorship W1982061234A5000030352 @default.
• W1982061234 hasAuthorship W1982061234A5005121596 @default.
• W1982061234 hasAuthorship W1982061234A5009414735 @default.
• W1982061234 hasAuthorship W1982061234A5051210772 @default.
• W1982061234 hasAuthorship W1982061234A5053370481 @default.
• W1982061234 hasAuthorship W1982061234A5056842523 @default.
• W1982061234 hasAuthorship W1982061234A5069892594 @default.
• W1982061234 hasAuthorship W1982061234A5074404662 @default.
• W1982061234 hasAuthorship W1982061234A5077194201 @default.
• W1982061234 hasAuthorship W1982061234A5083001869 @default.
• W1982061234 hasBestOaLocation W19820612341 @default.
• W1982061234 hasConcept C104317684 @default.
• W1982061234 hasConcept C127716648 @default.
• W1982061234 hasConcept C136449434 @default.
• W1982061234 hasConcept C185592680 @default.
• W1982061234 hasConcept C203014093 @default.
• W1982061234 hasConcept C22615655 @default.
• W1982061234 hasConcept C2775862500 @default.
• W1982061234 hasConcept C2776090121 @default.
• W1982061234 hasConcept C2776914184 @default.
• W1982061234 hasConcept C2778296632 @default.
• W1982061234 hasConcept C2779919695 @default.
• W1982061234 hasConcept C54009773 @default.
• W1982061234 hasConcept C54355233 @default.
• W1982061234 hasConcept C55493867 @default.
• W1982061234 hasConcept C79484868 @default.
• W1982061234 hasConcept C81885089 @default.
• W1982061234 hasConcept C86803240 @default.
• W1982061234 hasConcept C8891405 @default.
• W1982061234 hasConcept C90375314 @default.
• W1982061234 hasConcept C95444343 @default.
• W1982061234 hasConceptScore W1982061234C104317684 @default.
• W1982061234 hasConceptScore W1982061234C127716648 @default.
• W1982061234 hasConceptScore W1982061234C136449434 @default.
• W1982061234 hasConceptScore W1982061234C185592680 @default.
• W1982061234 hasConceptScore W1982061234C203014093 @default.
• W1982061234 hasConceptScore W1982061234C22615655 @default.
• W1982061234 hasConceptScore W1982061234C2775862500 @default.
• W1982061234 hasConceptScore W1982061234C2776090121 @default.
• W1982061234 hasConceptScore W1982061234C2776914184 @default.
• W1982061234 hasConceptScore W1982061234C2778296632 @default.
• W1982061234 hasConceptScore W1982061234C2779919695 @default.
• W1982061234 hasConceptScore W1982061234C54009773 @default.
• W1982061234 hasConceptScore W1982061234C54355233 @default.
• W1982061234 hasConceptScore W1982061234C55493867 @default.
• W1982061234 hasConceptScore W1982061234C79484868 @default.
• W1982061234 hasConceptScore W1982061234C81885089 @default.

• next