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• W1982070448 abstract "1 A variety of atropine-like drugs effective in the treatment of drug-induced extrapyramidal syndromes have been investigated with regard to their interaction with dopamine-containing neurones in rat brain. 2 Under some conditions benztropine, trihexyphenidyl, atropine and ethopropazine significantly antagonized the chlorpromazine-induced increase in subcortical concentrations of homovanillic acid. 3 Most of the atropine-like drugs investigated also decreased the turnover of dopamine in the subcortex as measured by following the disappearance of dopamine after administration of α-methyl-p-tyrosine. 4 These findings are suggestive that an imbalance between a dopaminergic and cholinergic system might be closely linked to the pathogenesis of extrapyramidal movement disorders." @default.
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• W1982070448 date "1972-02-01" @default.
• W1982070448 modified "2023-10-16" @default.
• W1982070448 title "Interaction of atropine-like drugs with dopamine-containing neurones in rat brain" @default.
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• W1982070448 doi "https://doi.org/10.1111/j.1476-5381.1972.tb07267.x" @default.
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