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• W1982070527 abstract "The power of the immune system represents a tantalizing mechanism for potential tumor eradication in patients with cancer. Unfortunately, most immunologic strategies designed to treat malignancy ultimately fail. Regulatory T cells (Tregs) entail a suppressive population of CD4+ T cells with a central role in the prevention of autoimmunity and the promotion of tolerance via their suppressive function on a broad repertoire of cellular targets. These regulatory activities, particularly on tumor antigen-presenting cells and cytotoxic antitumor cells, highlight Tregs as a critical immune-suppressing cell capable of affecting tumor-induced immune suppression. The purpose of this review is to highlight the current understanding of Tregs and their role in cancer, and to discuss proposed therapies to mitigate Treg-mediated immune escape." @default.
• W1982070527 created "2016-06-24" @default.
• W1982070527 creator A5006371106 @default.
• W1982070527 creator A5036784999 @default.
• W1982070527 date "2009-04-01" @default.
• W1982070527 modified "2023-10-10" @default.
• W1982070527 title "Suppressing the suppressor: Role of immunosuppressive regulatory T cells in cancer surgery" @default.
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• W1982070527 doi "https://doi.org/10.1016/j.surg.2008.12.013" @default.
• W1982070527 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19303982" @default.
• W1982070527 hasPublicationYear "2009" @default.
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