FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982075685> ?p ?o ?g. }

• W1982075685 endingPage "138" @default.
• W1982075685 startingPage "128" @default.
• W1982075685 abstract "We investigated the roles of kainate-, alpha-amino-3-hydroxy-5-methylisoxazol-4-propionate (AMPA)- and N-methyl-D-aspartate (NMDA)-receptors in mediating striatal kainate injection-induced decrease in the binding of acetylcholine M(1) receptors in rat forebrain. After unilateral intrastriatal injection of kainate (4 nmol), the bindings of [3H]kainate (10 nM), [3H]MK-801 (4 nM) and [3H]pirenzepine (4 nM) to the rat ipsilateral forebrain membranes declined, reaching the lowest on day 2 to 4 and recovering on day 8. Saturation binding studies, performed on day 2 post-injection, showed that kainate (1, 2, 4 nmol) dose-dependently decreased B(max) and K(d) of the three ligands. (+)-5-Methyl-10, 11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801), a selective NMDA receptor channel blocker, antagonised (from a dose of 4 nmol) kainate-induced decreases in the bindings of [3H]kainate (up to approximately 20%), [3H]MK-801 (up to approximately 90%) and [3H]pirenzepine (up to approximately 70%). In contrast, 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), a selective non-NMDA receptor antagonist, almost completely abolished (from a dose of 12 nmol) kainate-induced decreases in the bindings of all the three ligands (up to approximately 95-98%). Cyclothiazide, a selective potentiator that enhances AMPA receptor-mediated responses, significantly enhanced (from a dose of 4 nmol) kainate-induced decrease in the binding of [3H]kainate but not that of [3H]pirenzepine or [3H]MK-801. In summary, these results indicate that striatal kainate injection-induced decrease in the binding of acetylcholine M(1) receptors in rat forebrain is dependent on activation of kainate receptors and, to a certain extent, a consequent involvement of NMDA receptors. These and previous studies provide some evidence showing that kainate receptors might play a crucial role in regulating excitatory amino acids (EAA)-modulated cholinergic neurotransmission in the central nervous system (CNS)." @default.
• W1982075685 created "2016-06-24" @default.
• W1982075685 creator A5006366709 @default.
• W1982075685 creator A5049421341 @default.
• W1982075685 creator A5065576614 @default.
• W1982075685 creator A5077898942 @default.
• W1982075685 date "2000-11-01" @default.
• W1982075685 modified "2023-09-27" @default.
• W1982075685 title "Crucial role of kainate receptors in mediating striatal kainate injection-induced decrease in acetylcholine M1 receptor binding in rat forebrain" @default.
• W1982075685 cites W1637705010 @default.
• W1982075685 cites W1911312547 @default.
• W1982075685 cites W1965923895 @default.
• W1982075685 cites W1970620640 @default.
• W1982075685 cites W1972546023 @default.
• W1982075685 cites W1976289522 @default.
• W1982075685 cites W1980484115 @default.
• W1982075685 cites W1981300759 @default.
• W1982075685 cites W1987672715 @default.
• W1982075685 cites W2014379663 @default.
• W1982075685 cites W2017550651 @default.
• W1982075685 cites W2025350700 @default.
• W1982075685 cites W2040042998 @default.
• W1982075685 cites W2042963827 @default.
• W1982075685 cites W2043873927 @default.
• W1982075685 cites W2051770770 @default.
• W1982075685 cites W2053602738 @default.
• W1982075685 cites W2054405716 @default.
• W1982075685 cites W2054675912 @default.
• W1982075685 cites W2064760334 @default.
• W1982075685 cites W2070747761 @default.
• W1982075685 cites W2070785967 @default.
• W1982075685 cites W2072034156 @default.
• W1982075685 cites W2076140555 @default.
• W1982075685 cites W2078084904 @default.
• W1982075685 cites W2080667065 @default.
• W1982075685 cites W2082268337 @default.
• W1982075685 cites W2099597342 @default.
• W1982075685 cites W2126955976 @default.
• W1982075685 cites W2128635872 @default.
• W1982075685 cites W2137777161 @default.
• W1982075685 cites W2137924693 @default.
• W1982075685 cites W2172025026 @default.
• W1982075685 cites W2180941170 @default.
• W1982075685 cites W220594035 @default.
• W1982075685 cites W2219644706 @default.
• W1982075685 cites W2273738402 @default.
• W1982075685 cites W2340738174 @default.
• W1982075685 cites W2403094776 @default.
• W1982075685 cites W2413706335 @default.
• W1982075685 cites W2416160527 @default.
• W1982075685 cites W2419560600 @default.
• W1982075685 doi "https://doi.org/10.1016/s0006-8993(00)02857-2" @default.
• W1982075685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11056192" @default.
• W1982075685 hasPublicationYear "2000" @default.
• W1982075685 type Work @default.
• W1982075685 sameAs 1982075685 @default.
• W1982075685 citedByCount "1" @default.
• W1982075685 crossrefType "journal-article" @default.
• W1982075685 hasAuthorship W1982075685A5006366709 @default.
• W1982075685 hasAuthorship W1982075685A5049421341 @default.
• W1982075685 hasAuthorship W1982075685A5065576614 @default.
• W1982075685 hasAuthorship W1982075685A5077898942 @default.
• W1982075685 hasConcept C12554922 @default.
• W1982075685 hasConcept C126322002 @default.
• W1982075685 hasConcept C134018914 @default.
• W1982075685 hasConcept C160268369 @default.
• W1982075685 hasConcept C170493617 @default.
• W1982075685 hasConcept C185592680 @default.
• W1982075685 hasConcept C189184402 @default.
• W1982075685 hasConcept C2776108384 @default.
• W1982075685 hasConcept C2776885963 @default.
• W1982075685 hasConcept C2777836312 @default.
• W1982075685 hasConcept C2778616617 @default.
• W1982075685 hasConcept C2779715522 @default.
• W1982075685 hasConcept C2779803574 @default.
• W1982075685 hasConcept C529278444 @default.
• W1982075685 hasConcept C55493867 @default.
• W1982075685 hasConcept C61174792 @default.
• W1982075685 hasConcept C67018056 @default.
• W1982075685 hasConcept C71924100 @default.
• W1982075685 hasConcept C86803240 @default.
• W1982075685 hasConcept C98274493 @default.
• W1982075685 hasConceptScore W1982075685C12554922 @default.
• W1982075685 hasConceptScore W1982075685C126322002 @default.
• W1982075685 hasConceptScore W1982075685C134018914 @default.
• W1982075685 hasConceptScore W1982075685C160268369 @default.
• W1982075685 hasConceptScore W1982075685C170493617 @default.
• W1982075685 hasConceptScore W1982075685C185592680 @default.
• W1982075685 hasConceptScore W1982075685C189184402 @default.
• W1982075685 hasConceptScore W1982075685C2776108384 @default.
• W1982075685 hasConceptScore W1982075685C2776885963 @default.
• W1982075685 hasConceptScore W1982075685C2777836312 @default.
• W1982075685 hasConceptScore W1982075685C2778616617 @default.
• W1982075685 hasConceptScore W1982075685C2779715522 @default.
• W1982075685 hasConceptScore W1982075685C2779803574 @default.
• W1982075685 hasConceptScore W1982075685C529278444 @default.
• W1982075685 hasConceptScore W1982075685C55493867 @default.
• W1982075685 hasConceptScore W1982075685C61174792 @default.

• next