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- W1982085282 abstract "The AMP-activated protein kinase is a sensor of cellular energy status that is found in all eukaryotic cells. It is activated by rising AMP and falling ATP by a complex mechanism that results in an ultrasensitive response. The functions of the different domains on the three subunits of the alphabetagamma heterotrimer are slowly being unravelled, and a recent development has been the identification of a glycogen-binding domain on the beta subunit. Along with findings that high cellular glycogen represses kinase activation, this suggests that the system may be a sensor of glycogen content as well as of AMP and ATP. New insights have been obtained into the sequence and structural features by which the kinase recognises its downstream target proteins, and these are discussed. Once activated by depletion of cellular energy reserves, the kinase switches on ATP-producing catabolic pathways and switches off ATP-consuming processes, both via direct phosphorylation of regulatory proteins and via indirect effects on gene expression. A survey of the range of downstream targets for this important signalling pathway is presented." @default.
- W1982085282 created "2016-06-24" @default.
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- W1982085282 date "2003-05-27" @default.
- W1982085282 modified "2023-10-14" @default.
- W1982085282 title "Management of cellular energy by the AMP-activated protein kinase system" @default.
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- W1982085282 cites W1955808217 @default.
- W1982085282 cites W1959374451 @default.
- W1982085282 cites W1963540950 @default.
- W1982085282 cites W1967711037 @default.
- W1982085282 cites W1967893549 @default.
- W1982085282 cites W1973749169 @default.
- W1982085282 cites W1974870493 @default.
- W1982085282 cites W1975883334 @default.
- W1982085282 cites W1978763812 @default.
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- W1982085282 doi "https://doi.org/10.1016/s0014-5793(03)00560-x" @default.
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