Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982085295> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W1982085295 endingPage "445" @default.
- W1982085295 startingPage "434" @default.
- W1982085295 abstract "Abstract Receptors for the specific muscarinic radioligand [3H]quinuclidinyl benzilate ([3H]QNB) were solubilized by digitonin from a particulate preparation of bovine brain without significant alteration in binding affinities for muscarinic antagonists. Electron microscopy and sucrose density gradient sedimentation analysis confirmed the solubility of these receptors in aqueous solutions of digitonin. Equilibrium and kinetic studies of [3H]QNB binding to solubilized receptors indicated that binding was stereoselective and was blocked by muscarinic compounds. These tests permit tentative identification of digitonin-solubilized [3H]QNB binding sites as muscarinic acetylcholine receptors. Digitonin-solubilized receptors were homogeneous with respect to sedimentation behavior and binding affinities for agonist and antagonist drugs, unlike membrane-bound receptors. Enzyme digestion studies and treatment with group-specific reagents indicated that muscarinic receptors are proteins whose binding activity could be disrupted by reduction with dithiothreitol or by modification of sulfhydryl residues." @default.
- W1982085295 created "2016-06-24" @default.
- W1982085295 creator A5048287204 @default.
- W1982085295 date "1978-10-01" @default.
- W1982085295 modified "2023-09-24" @default.
- W1982085295 title "Specific [3H]quinuclidinyl benzilate binding activity in Digitonin-solubilized preparations from bovine brain" @default.
- W1982085295 cites W1481193748 @default.
- W1982085295 cites W150216847 @default.
- W1982085295 cites W1506578135 @default.
- W1982085295 cites W1531281247 @default.
- W1982085295 cites W1556012018 @default.
- W1982085295 cites W1565296698 @default.
- W1982085295 cites W1585579824 @default.
- W1982085295 cites W1611482599 @default.
- W1982085295 cites W1775749144 @default.
- W1982085295 cites W1971048984 @default.
- W1982085295 cites W1975645377 @default.
- W1982085295 cites W1979528769 @default.
- W1982085295 cites W1982218403 @default.
- W1982085295 cites W1983649348 @default.
- W1982085295 cites W1997480152 @default.
- W1982085295 cites W2022377078 @default.
- W1982085295 cites W2024990200 @default.
- W1982085295 cites W2035739592 @default.
- W1982085295 cites W2046890734 @default.
- W1982085295 cites W2049651620 @default.
- W1982085295 cites W2056656915 @default.
- W1982085295 cites W2059343465 @default.
- W1982085295 cites W2060186952 @default.
- W1982085295 cites W2069731032 @default.
- W1982085295 cites W2070010879 @default.
- W1982085295 cites W2071952053 @default.
- W1982085295 cites W2083522762 @default.
- W1982085295 cites W2092083211 @default.
- W1982085295 cites W2093237151 @default.
- W1982085295 cites W2333083481 @default.
- W1982085295 cites W4211109628 @default.
- W1982085295 doi "https://doi.org/10.1016/0003-9861(78)90296-5" @default.
- W1982085295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/718161" @default.
- W1982085295 hasPublicationYear "1978" @default.
- W1982085295 type Work @default.
- W1982085295 sameAs 1982085295 @default.
- W1982085295 citedByCount "82" @default.
- W1982085295 crossrefType "journal-article" @default.
- W1982085295 hasAuthorship W1982085295A5048287204 @default.
- W1982085295 hasConcept C170493617 @default.
- W1982085295 hasConcept C181199279 @default.
- W1982085295 hasConcept C185592680 @default.
- W1982085295 hasConcept C2778920010 @default.
- W1982085295 hasConcept C2908651707 @default.
- W1982085295 hasConcept C33789571 @default.
- W1982085295 hasConcept C4863142 @default.
- W1982085295 hasConcept C55493867 @default.
- W1982085295 hasConceptScore W1982085295C170493617 @default.
- W1982085295 hasConceptScore W1982085295C181199279 @default.
- W1982085295 hasConceptScore W1982085295C185592680 @default.
- W1982085295 hasConceptScore W1982085295C2778920010 @default.
- W1982085295 hasConceptScore W1982085295C2908651707 @default.
- W1982085295 hasConceptScore W1982085295C33789571 @default.
- W1982085295 hasConceptScore W1982085295C4863142 @default.
- W1982085295 hasConceptScore W1982085295C55493867 @default.
- W1982085295 hasIssue "2" @default.
- W1982085295 hasLocation W19820852951 @default.
- W1982085295 hasLocation W19820852952 @default.
- W1982085295 hasOpenAccess W1982085295 @default.
- W1982085295 hasPrimaryLocation W19820852951 @default.
- W1982085295 hasRelatedWork W1595232957 @default.
- W1982085295 hasRelatedWork W1982085295 @default.
- W1982085295 hasRelatedWork W1982486473 @default.
- W1982085295 hasRelatedWork W1988059667 @default.
- W1982085295 hasRelatedWork W2021440827 @default.
- W1982085295 hasRelatedWork W2032291527 @default.
- W1982085295 hasRelatedWork W2041880626 @default.
- W1982085295 hasRelatedWork W2352115104 @default.
- W1982085295 hasRelatedWork W2402086118 @default.
- W1982085295 hasRelatedWork W2468728493 @default.
- W1982085295 hasVolume "190" @default.
- W1982085295 isParatext "false" @default.
- W1982085295 isRetracted "false" @default.
- W1982085295 magId "1982085295" @default.
- W1982085295 workType "article" @default.