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- W1982091777 abstract "During cell differentiation, gene expression is regulated at multiple levels which is only partially captured by transcription profiling. In recent years it became increasingly clear that post-translational modifications of core histones and post-transcriptional regulation by RNA-binding proteins and microRNAs play an important role during differentiation. Recent advances in mass spectrometry-based quantitative proteomics now allow for genome-wide analyses at the protein level. This technology provides a powerful toolbox that can be used to study different levels of gene regulation and reveal their importance during development of multi-cellular organisms. We highlight recent studies and indicate how quantitative proteomics can be employed to investigate cell differentiation in the future." @default.
- W1982091777 created "2016-06-24" @default.
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- W1982091777 date "2009-12-01" @default.
- W1982091777 modified "2023-09-28" @default.
- W1982091777 title "Quantitative proteomics: a tool to assess cell differentiation" @default.
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- W1982091777 doi "https://doi.org/10.1016/j.ceb.2009.09.003" @default.
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