FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982092502> ?p ?o ?g. }

• W1982092502 abstract "Bovine tuberculosis (BTB), caused by infection with Mycobacterium bovis, is a major endemic disease affecting cattle populations worldwide, despite the implementation of stringent surveillance and control programs in many countries. The development of high-throughput functional genomics technologies, including gene expression microarrays and RNA sequencing (RNA-seq), has enabled detailed analysis of the host transcriptome to M. bovis infection, particularly at the macrophage and peripheral blood level. In the present study, we have analyzed the peripheral blood leukocyte (PBL) transcriptome of eight natural M. bovis-infected and eight age- and sex-matched non-infected control Holstein-Friesian animals using RNA-seq. In addition, we compared gene expression profiles generated using RNA-seq with those previously generated using the high-density Affymetrix® GeneChip® Bovine Genome Array platform from the same PBL-extracted RNA. A total of 3,250 differentially expressed (DE) annotated genes were detected in the M. bovis-infected samples relative to the controls (adjusted P-value ≤ 0.05), with the number of genes displaying decreased relative expression (1,671) exceeding those with increased relative expression (1,579). Ingenuity® Systems Pathway Analysis (IPA) of all DE genes revealed enrichment for genes with immune function. Notably, transcriptional suppression was observed among several of the top ranking canonical pathways including Leukocyte Extravasation Signaling. Comparative platform analysis demonstrated that RNA-seq detected a larger number of annotated DE genes (3,250) relative to the microarray (1,398), of which 917 genes were common to both technologies and displayed the same direction of expression. Finally, we show that RNA-seq had an increased dynamic range compared to the microarray for estimating differential gene expression." @default.
• W1982092502 created "2016-06-24" @default.
• W1982092502 creator A5002853430 @default.
• W1982092502 creator A5003377656 @default.
• W1982092502 creator A5006830889 @default.
• W1982092502 creator A5009989247 @default.
• W1982092502 creator A5011090593 @default.
• W1982092502 creator A5023813027 @default.
• W1982092502 creator A5023984745 @default.
• W1982092502 creator A5047418884 @default.
• W1982092502 creator A5050298049 @default.
• W1982092502 creator A5060999913 @default.
• W1982092502 creator A5063389696 @default.
• W1982092502 creator A5075853590 @default.
• W1982092502 creator A5091548602 @default.
• W1982092502 date "2014-08-26" @default.
• W1982092502 modified "2023-09-28" @default.
• W1982092502 title "RNA-seq Transcriptional Profiling of Peripheral Blood Leukocytes from Cattle Infected with Mycobacterium bovis" @default.
• W1982092502 cites W1853482255 @default.
• W1982092502 cites W1963732961 @default.
• W1982092502 cites W1969841262 @default.
• W1982092502 cites W1981509058 @default.
• W1982092502 cites W1982794340 @default.
• W1982092502 cites W1985028690 @default.
• W1982092502 cites W1992629451 @default.
• W1982092502 cites W1995070233 @default.
• W1982092502 cites W1999050546 @default.
• W1982092502 cites W1999169296 @default.
• W1982092502 cites W2005852056 @default.
• W1982092502 cites W2012016610 @default.
• W1982092502 cites W2015449387 @default.
• W1982092502 cites W2016588508 @default.
• W1982092502 cites W2016859011 @default.
• W1982092502 cites W2021337850 @default.
• W1982092502 cites W2025482164 @default.
• W1982092502 cites W2028327662 @default.
• W1982092502 cites W2035809865 @default.
• W1982092502 cites W2036493275 @default.
• W1982092502 cites W2041313118 @default.
• W1982092502 cites W2041944853 @default.
• W1982092502 cites W2042679578 @default.
• W1982092502 cites W2046290634 @default.
• W1982092502 cites W2052791500 @default.
• W1982092502 cites W2055861579 @default.
• W1982092502 cites W2060842569 @default.
• W1982092502 cites W2063975983 @default.
• W1982092502 cites W2064641822 @default.
• W1982092502 cites W2064736441 @default.
• W1982092502 cites W2065230752 @default.
• W1982092502 cites W2067147999 @default.
• W1982092502 cites W2069716488 @default.
• W1982092502 cites W2080837438 @default.
• W1982092502 cites W2081098333 @default.
• W1982092502 cites W2087187487 @default.
• W1982092502 cites W2087457971 @default.
• W1982092502 cites W2093436540 @default.
• W1982092502 cites W2094678200 @default.
• W1982092502 cites W2094746649 @default.
• W1982092502 cites W2095691309 @default.
• W1982092502 cites W2095891614 @default.
• W1982092502 cites W2104146295 @default.
• W1982092502 cites W2107018762 @default.
• W1982092502 cites W2109543073 @default.
• W1982092502 cites W2112398805 @default.
• W1982092502 cites W2112686497 @default.
• W1982092502 cites W2114104545 @default.
• W1982092502 cites W2117433447 @default.
• W1982092502 cites W2118227812 @default.
• W1982092502 cites W2118249480 @default.
• W1982092502 cites W2118502498 @default.
• W1982092502 cites W2120358449 @default.
• W1982092502 cites W2120682915 @default.
• W1982092502 cites W2121211805 @default.
• W1982092502 cites W2123940675 @default.
• W1982092502 cites W2125686203 @default.
• W1982092502 cites W2127372456 @default.
• W1982092502 cites W2127697626 @default.
• W1982092502 cites W2138207763 @default.
• W1982092502 cites W2139564620 @default.
• W1982092502 cites W2145825942 @default.
• W1982092502 cites W2146341019 @default.
• W1982092502 cites W2161106528 @default.
• W1982092502 cites W2162934206 @default.
• W1982092502 cites W2165801297 @default.
• W1982092502 cites W2166833739 @default.
• W1982092502 cites W2168546066 @default.
• W1982092502 cites W2169456326 @default.
• W1982092502 cites W2170066154 @default.
• W1982092502 doi "https://doi.org/10.3389/fimmu.2014.00396" @default.
• W1982092502 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4143615" @default.
• W1982092502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25206354" @default.
• W1982092502 hasPublicationYear "2014" @default.
• W1982092502 type Work @default.
• W1982092502 sameAs 1982092502 @default.
• W1982092502 citedByCount "48" @default.
• W1982092502 countsByYear W19820925022015 @default.
• W1982092502 countsByYear W19820925022016 @default.
• W1982092502 countsByYear W19820925022017 @default.
• W1982092502 countsByYear W19820925022018 @default.
• W1982092502 countsByYear W19820925022019 @default.

• next