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• W1982102987 abstract "The effects of interactions between N-methyl-D-aspartate (NMDA) and nitric oxide on ultrasonic vocalizations, motor activity and body temperature was investigated in 9-10-day-old rat pups. The competitive NMDA receptor antagonist, 3-((+/-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP), and the nitric oxide synthase inhibitor, nitro-L-arginine-methyl ester (L-NAME), decreased the emission of ultrasonic vocalizations while NMDA and the nitric oxide precursor, L-arginine, produced a trend toward increased emission of ultrasonic vocalizations. CCP also attenuated the geotaxic response. Co-administration of CPP with L-NAME virtually abolished the emission of ultrasonic vocalizations and the ability to show the geotaxic response while co-administration of NMDA with L-arginine increased the emission of ultrasonic vocalizations and decreased body temperature with no effect on the geotaxic response. NMDA and L-arginine reversed the effects of L-NAME, but not of CPP, on ultrasonic vocalizations. L-arginine but not NMDA antagonized the effect of CPP on the geotaxic response. Our results confirmed the functional coupling between NMDA receptor activation and nitric oxide in modulating anxiety-like behavior and motor coordination in infant rats." @default.
• W1982102987 created "2016-06-24" @default.
• W1982102987 creator A5046954307 @default.
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• W1982102987 date "2000-11-01" @default.
• W1982102987 modified "2023-09-24" @default.
• W1982102987 title "Interactions between N-methyl-d-aspartate and nitric oxide in the modulation of ultrasonic vocalizations of infant rats" @default.
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• W1982102987 doi "https://doi.org/10.1016/s0014-2999(00)00791-3" @default.
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