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- W1982105865 abstract "Sirs, I read with interest the paper by Schenk et al.1 where they examined possible mechanisms for severe hypergastrinaemia during long-term omeprazole treatment for gastro-oesophageal reflux disease. They found that Helicobacter pylori infection was associated with higher blood gastrin values during omeprazole treatment.1 They defined severe hypergastrinaemia as values above 400 ng/L,1 although they gave no reason for choosing this value as a limit. Such an occasional value gives the readers the impression that serum gastrin values below this limit are safe. However, there is a continuous concentration-dependent response for the effect of gastrin, both for stimulation of function2, 3 and growth.4, 5 Therefore it is artificial to define hypergastrinaemia into severe and not severe forms. The reason why some patients with H. pylori infection develop higher gastrin values than other patients during treatment with proton pump inhibitors, is probably due to a H. pylori induced atrophic gastritis affecting the oxyntic mucosa and thus reducing gastric acidity.6 Such an increase in intragastric pH would further decrease the inhibition of the G-cell.7 In conclusion, proton pump inhibitors induce hypergastrinaemia by their lowering of gastric acidity and thereby removal of inhibition of the gastrin cell. The degree of hypergastrinaemia induced by inhibitors of gastric acid secretion depends on the resulting intragastric acidity. A division between severe and not severe hypergastrinaemia is not based on biological knowledge, and may be misleading." @default.
- W1982105865 created "2016-06-24" @default.
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- W1982105865 date "1999-03-01" @default.
- W1982105865 modified "2023-10-16" @default.
- W1982105865 title "Hypergastrinaemia with long-term omeprazole treatment" @default.
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- W1982105865 doi "https://doi.org/10.1046/j.1365-2036.1999.0467c.x" @default.
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