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• W1982109246 abstract "We reported that high frequency intensive interval training, i.e. once every two days, during 20 days of unloading prevented atrophy of the quadriceps femoris (QF) muscles. However, it is unclear the minimum training frequency for prevention of atrophy and dysfunction during unloading. PURPOSE: The purpose of this study was to clarify the effect of low frequency intensive interval training on volume and function of human skeletal muscle during unilateral lower limb unloading. METHODS: Sixteen healthy men were divided into two groups: unloading with training (Tr group, n = 8) and unloading only (UL group, n = 8). Both groups underwent lower limb unloading of either the left or right leg for 20 days. Exercise training consisted of an interval exercise protocol of 2- to 3-min intervals alternating between 40% and 80% of peak oxygen uptake with the unloaded leg on every four days during the experimental period. Maximum voluntary contraction (MVC) during isometric knee extension was measured. Anatomical magnetic resonance imaging (MRI) of the thighs was taken to calculate volume of the QF muscles. Muscle functional MRI (spin-echo, TR/TE 2000/30, 60 msec) of the QF muscles was obtained during submaximal dynamic knee extension exercise (5 sets of 10 repetitions) at a load of 30%MVC. RESULTS: MVC of the unloading leg for the Tr (537 ± 84 N to 444 ± 65 N; -17%, P < 0.05) and UL (537 ± 119 N to 451 ± 105 N; -16%, P < 0.05) groups significantly decreased after unloading. The volume of the QF muscles in the unloading leg for the Tr group did not change after unloading, from 1171 ± 112 cm3 to 1159 ± 98 cm3 (-1%); however, that for the UL group significantly decreased, from 1225 ± 241 cm3 to 1118 ± 232 cm3 (-9%) (P < 0.05). There was no significant difference in muscle functional MRI between Tr group and UL group. No significant change was found in any parameters of the supported leg for either groups. CONCLUSIONS: These results suggest that low frequency intensive interval training during 20 days of unloading was effective for prevention of atrophy; however, no beneficial training effect would be expected for prevention of muscle dysfunction by this training frequency." @default.
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• W1982109246 date "2008-05-01" @default.
• W1982109246 modified "2023-10-16" @default.
• W1982109246 title "Effects Of Low Frequency Intensive Interval Training On Muscle Atrophy And Function During Unloading" @default.
• W1982109246 doi "https://doi.org/10.1249/01.mss.0000323404.93414.9d" @default.
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