FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982110841> ?p ?o ?g. }

• W1982110841 endingPage "1039" @default.
• W1982110841 startingPage "1029" @default.
• W1982110841 abstract "A new modelling analysis was developed to assess insulin sensitivity with a tracer-modified intravenous glucose tolerance test (IVGTT). IVGTTs were performed in 5 normal (NGT) and 7 non-insulin-dependent diabetic (NIDDM) subjects. A 300 mg/kg glucose bolus containing [6,6-(2)H2]glucose was given at time 0. After 20 min, insulin was infused for 5 min (NGT, 0.03; NIDDM, 0.05 U/kg). Concentrations of tracer, glucose, insulin and C-peptide were measured for 240 min. A circulatory model for glucose kinetics was used. Glucose clearance was assumed to depend linearly on plasma insulin concentration delayed. Model parameters were: basal glucose clearance (Cl(b)), glucose clearance at 600 pmol/l insulin concentration (Cl600), basal glucose production (Pb), basal insulin sensitivity index (BSI = Cl(b)/basal insulin concentration); incremental insulin sensitivity index (ISI = slope of the relationship between insulin concentration and glucose clearance). Insulin secretion was calculated by deconvolution of C-peptide data. Indices of basal pancreatic sensitivity (PSIb) and first (PSI1) and second-phase (PSI2) sensitivity were calculated by normalizing insulin secretion to the prevailing glucose levels. Diabetic subjects were found to be insulin resistant (BSI: 2.3 +/- 0.6 vs 0.76 +/- 0.18 ml x min(-1) x m(-2) x pmol/l(-1), p < 0.02; ISI: 0.40 +/- 0.06 vs 0.13 +/- 0.05 ml x min(-1) x m(-2) x pmol/l(-1), p < 0.02; Cl600: 333 +/- 47 vs 137 +/- 26 ml x min(-1) x m(-2), p < 0.01; NGT vs NIDDM). Pb was not elevated in NIDDM (588 +/- 169 vs 606 +/- 123 micromol x min(-1) x m(-2), NGT vs NIDDM). Hepatic insulin resistance was however present as basal glucose and insulin were higher. PSI1 was impaired in NIDDM (67 +/- 15 vs 12 +/- 7 pmol x min x m(-2) x mmol/l(-1), p < 0.02; NGT vs NIDDM). In NGT and in a subset of NIDDM subjects (n = 4), PSIb was inversely correlated with BSI (r = 0.95, p < 0.0001, log transformation). This suggests the existence of a compensatory mechanism that increases pancreatic sensitivity in the presence of insulin resistance, which is normal in some NIDDM subjects and impaired in others. In conclusion, using a simple test the present analysis provides a rich set of parameters characterizing glucose metabolism and insulin secretion, agrees with the literature, and provides some new information on the relationship between insulin sensitivity and secretion." @default.
• W1982110841 created "2016-06-24" @default.
• W1982110841 creator A5091886237 @default.
• W1982110841 date "1998-08-19" @default.
• W1982110841 modified "2023-10-18" @default.
• W1982110841 title "Assessment of insulin sensitivity and secretion with the labelled intravenous glucose tolerance test: improved modelling analysis" @default.
• W1982110841 cites W1771429046 @default.
• W1982110841 cites W1860443407 @default.
• W1982110841 cites W1944705852 @default.
• W1982110841 cites W1979223224 @default.
• W1982110841 cites W2007283569 @default.
• W1982110841 cites W2018459966 @default.
• W1982110841 cites W2027034555 @default.
• W1982110841 cites W2035899318 @default.
• W1982110841 cites W2036400933 @default.
• W1982110841 cites W2045622447 @default.
• W1982110841 cites W2047922146 @default.
• W1982110841 cites W2050082711 @default.
• W1982110841 cites W2053464136 @default.
• W1982110841 cites W2059325517 @default.
• W1982110841 cites W2060591324 @default.
• W1982110841 cites W2061309116 @default.
• W1982110841 cites W2065544193 @default.
• W1982110841 cites W2070800088 @default.
• W1982110841 cites W2070862761 @default.
• W1982110841 cites W2078645108 @default.
• W1982110841 cites W2100588873 @default.
• W1982110841 cites W2112418742 @default.
• W1982110841 cites W2113637996 @default.
• W1982110841 cites W2115486658 @default.
• W1982110841 cites W2125624587 @default.
• W1982110841 cites W2127283734 @default.
• W1982110841 cites W2129984456 @default.
• W1982110841 cites W2133137653 @default.
• W1982110841 cites W2153716175 @default.
• W1982110841 cites W2172957830 @default.
• W1982110841 cites W2196957880 @default.
• W1982110841 cites W2228342512 @default.
• W1982110841 cites W2342009246 @default.
• W1982110841 cites W2403362455 @default.
• W1982110841 cites W2441986625 @default.
• W1982110841 cites W617896656 @default.
• W1982110841 doi "https://doi.org/10.1007/s001250051027" @default.
• W1982110841 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9754821" @default.
• W1982110841 hasPublicationYear "1998" @default.
• W1982110841 type Work @default.
• W1982110841 sameAs 1982110841 @default.
• W1982110841 citedByCount "45" @default.
• W1982110841 countsByYear W19821108412012 @default.
• W1982110841 countsByYear W19821108412013 @default.
• W1982110841 countsByYear W19821108412015 @default.
• W1982110841 countsByYear W19821108412016 @default.
• W1982110841 countsByYear W19821108412017 @default.
• W1982110841 countsByYear W19821108412019 @default.
• W1982110841 countsByYear W19821108412020 @default.
• W1982110841 countsByYear W19821108412022 @default.
• W1982110841 crossrefType "journal-article" @default.
• W1982110841 hasAuthorship W1982110841A5091886237 @default.
• W1982110841 hasBestOaLocation W19821108411 @default.
• W1982110841 hasConcept C126322002 @default.
• W1982110841 hasConcept C134018914 @default.
• W1982110841 hasConcept C185592680 @default.
• W1982110841 hasConcept C2777391703 @default.
• W1982110841 hasConcept C2778024521 @default.
• W1982110841 hasConcept C2778875212 @default.
• W1982110841 hasConcept C2779306644 @default.
• W1982110841 hasConcept C2780352109 @default.
• W1982110841 hasConcept C3017594256 @default.
• W1982110841 hasConcept C3017594758 @default.
• W1982110841 hasConcept C3020574416 @default.
• W1982110841 hasConcept C43376680 @default.
• W1982110841 hasConcept C555293320 @default.
• W1982110841 hasConcept C71924100 @default.
• W1982110841 hasConceptScore W1982110841C126322002 @default.
• W1982110841 hasConceptScore W1982110841C134018914 @default.
• W1982110841 hasConceptScore W1982110841C185592680 @default.
• W1982110841 hasConceptScore W1982110841C2777391703 @default.
• W1982110841 hasConceptScore W1982110841C2778024521 @default.
• W1982110841 hasConceptScore W1982110841C2778875212 @default.
• W1982110841 hasConceptScore W1982110841C2779306644 @default.
• W1982110841 hasConceptScore W1982110841C2780352109 @default.
• W1982110841 hasConceptScore W1982110841C3017594256 @default.
• W1982110841 hasConceptScore W1982110841C3017594758 @default.
• W1982110841 hasConceptScore W1982110841C3020574416 @default.
• W1982110841 hasConceptScore W1982110841C43376680 @default.
• W1982110841 hasConceptScore W1982110841C555293320 @default.
• W1982110841 hasConceptScore W1982110841C71924100 @default.
• W1982110841 hasIssue "9" @default.
• W1982110841 hasLocation W19821108411 @default.
• W1982110841 hasLocation W19821108412 @default.
• W1982110841 hasOpenAccess W1982110841 @default.
• W1982110841 hasPrimaryLocation W19821108411 @default.
• W1982110841 hasRelatedWork W138803513 @default.
• W1982110841 hasRelatedWork W2000308085 @default.
• W1982110841 hasRelatedWork W2016328345 @default.
• W1982110841 hasRelatedWork W2048226041 @default.
• W1982110841 hasRelatedWork W2048352852 @default.
• W1982110841 hasRelatedWork W2068166803 @default.

• next