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- W1982111692 abstract "Infection with group A streptococcus (GAS) can result in a number of diseases, some of which are potentially life-threatening. The oral–nasal mucosa is a primary site of GAS infection, and a mucosally active vaccine candidate could form the basis of an antidisease and transmission-blocking GAS vaccine. In the present study, a peptide from the GAS M protein (J14) representing a B cell epitope was incorporated alongside a universal T cell helper epitope and a Toll-like receptor 2 targeting lipid moiety to form lipopeptide constructs. Through structure activity studies, we identified a vaccine candidate that induces J14-specific mucosal and systemic antibody responses when administered intranasally without additional adjuvants. The systemic antibodies elicited were capable of inhibiting the growth of GAS. In addition, J14-specific mucosal antibodies corresponded with reduced throat colonization after respiratory GAS challenge. These preclinical experiments show that this lipopeptide could form the basis of an optimal needle-free mucosal GAS vaccine." @default.
- W1982111692 created "2016-06-24" @default.
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- W1982111692 date "2012-09-25" @default.
- W1982111692 modified "2023-10-18" @default.
- W1982111692 title "Structure–Activity Relationship for the Development of a Self-Adjuvanting Mucosally Active Lipopeptide Vaccine against Streptococcus pyogenes" @default.
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- W1982111692 doi "https://doi.org/10.1021/jm301074n" @default.
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