FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982118908> ?p ?o ?g. }

• W1982118908 endingPage "3815" @default.
• W1982118908 startingPage "3804" @default.
• W1982118908 abstract "Some protein-coding genes in metazoan genomes contain a minor class of introns that are excised by a distinct, low-abundance spliceosome. We have developed a quantitative RT-PCR assay that allows comparison of the relative rates of intron removal from the transcripts present in a pre-mRNA population. We show that the U12-type introns are more slowly spliced than the major-class (U2-type) introns from three endogenous pre-mRNAs in human tissue culture cells. In Drosophila melanogaster S2 cells, using minigene constructs designed to produce nearly identical mRNAs, we observe increased expression of fluorescent protein and mature mRNA upon mutation of a U12-type to a U2-type intron. These results provide evidence that the level of gene expression in vivo is lowered by the presence of a U12-type intron and implicate the U12-type spliceosome as a target in the post-transcriptional regulation of gene expression." @default.
• W1982118908 created "2016-06-24" @default.
• W1982118908 creator A5035064101 @default.
• W1982118908 creator A5061890532 @default.
• W1982118908 creator A5065482198 @default.
• W1982118908 date "2002-07-15" @default.
• W1982118908 modified "2023-09-22" @default.
• W1982118908 title "The splicing of U12-type introns can be a rate-limiting step in gene expression" @default.
• W1982118908 cites W1482020744 @default.
• W1982118908 cites W1560703397 @default.
• W1982118908 cites W1569955072 @default.
• W1982118908 cites W1586993244 @default.
• W1982118908 cites W1771001171 @default.
• W1982118908 cites W1918900522 @default.
• W1982118908 cites W1930994287 @default.
• W1982118908 cites W1965396892 @default.
• W1982118908 cites W1968072881 @default.
• W1982118908 cites W2001894746 @default.
• W1982118908 cites W2007995145 @default.
• W1982118908 cites W2021525576 @default.
• W1982118908 cites W2027265085 @default.
• W1982118908 cites W2029047331 @default.
• W1982118908 cites W2035136477 @default.
• W1982118908 cites W2036969473 @default.
• W1982118908 cites W2039350702 @default.
• W1982118908 cites W2050502168 @default.
• W1982118908 cites W2051490611 @default.
• W1982118908 cites W2056617805 @default.
• W1982118908 cites W2065905166 @default.
• W1982118908 cites W2072981456 @default.
• W1982118908 cites W2083010720 @default.
• W1982118908 cites W2090850551 @default.
• W1982118908 cites W2101810447 @default.
• W1982118908 cites W2110643873 @default.
• W1982118908 cites W2112675456 @default.
• W1982118908 cites W2114827591 @default.
• W1982118908 cites W2120763468 @default.
• W1982118908 cites W2121134984 @default.
• W1982118908 cites W2122194929 @default.
• W1982118908 cites W2146760000 @default.
• W1982118908 cites W2149783843 @default.
• W1982118908 cites W2161371497 @default.
• W1982118908 cites W2171171901 @default.
• W1982118908 cites W276752974 @default.
• W1982118908 doi "https://doi.org/10.1093/emboj/cdf297" @default.
• W1982118908 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/126102" @default.
• W1982118908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12110592" @default.
• W1982118908 hasPublicationYear "2002" @default.
• W1982118908 type Work @default.
• W1982118908 sameAs 1982118908 @default.
• W1982118908 citedByCount "132" @default.
• W1982118908 countsByYear W19821189082012 @default.
• W1982118908 countsByYear W19821189082013 @default.
• W1982118908 countsByYear W19821189082014 @default.
• W1982118908 countsByYear W19821189082015 @default.
• W1982118908 countsByYear W19821189082016 @default.
• W1982118908 countsByYear W19821189082017 @default.
• W1982118908 countsByYear W19821189082018 @default.
• W1982118908 countsByYear W19821189082019 @default.
• W1982118908 countsByYear W19821189082020 @default.
• W1982118908 countsByYear W19821189082021 @default.
• W1982118908 countsByYear W19821189082022 @default.
• W1982118908 countsByYear W19821189082023 @default.
• W1982118908 crossrefType "journal-article" @default.
• W1982118908 hasAuthorship W1982118908A5035064101 @default.
• W1982118908 hasAuthorship W1982118908A5061890532 @default.
• W1982118908 hasAuthorship W1982118908A5065482198 @default.
• W1982118908 hasBestOaLocation W19821189082 @default.
• W1982118908 hasConcept C102063271 @default.
• W1982118908 hasConcept C104317684 @default.
• W1982118908 hasConcept C150194340 @default.
• W1982118908 hasConcept C153911025 @default.
• W1982118908 hasConcept C165864922 @default.
• W1982118908 hasConcept C166342232 @default.
• W1982118908 hasConcept C40000846 @default.
• W1982118908 hasConcept C54355233 @default.
• W1982118908 hasConcept C54458228 @default.
• W1982118908 hasConcept C67705224 @default.
• W1982118908 hasConcept C72994624 @default.
• W1982118908 hasConcept C86803240 @default.
• W1982118908 hasConcept C94671646 @default.
• W1982118908 hasConceptScore W1982118908C102063271 @default.
• W1982118908 hasConceptScore W1982118908C104317684 @default.
• W1982118908 hasConceptScore W1982118908C150194340 @default.
• W1982118908 hasConceptScore W1982118908C153911025 @default.
• W1982118908 hasConceptScore W1982118908C165864922 @default.
• W1982118908 hasConceptScore W1982118908C166342232 @default.
• W1982118908 hasConceptScore W1982118908C40000846 @default.
• W1982118908 hasConceptScore W1982118908C54355233 @default.
• W1982118908 hasConceptScore W1982118908C54458228 @default.
• W1982118908 hasConceptScore W1982118908C67705224 @default.
• W1982118908 hasConceptScore W1982118908C72994624 @default.
• W1982118908 hasConceptScore W1982118908C86803240 @default.
• W1982118908 hasConceptScore W1982118908C94671646 @default.
• W1982118908 hasIssue "14" @default.
• W1982118908 hasLocation W19821189081 @default.
• W1982118908 hasLocation W19821189082 @default.
• W1982118908 hasLocation W19821189083 @default.

• next