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- W1982120847 abstract "The blood concentration, renal excretion, and molecular-size distribution of 6-O-hydroxyethyl starch (6-O-HES) and 2-O-hydroxyethyl starch (2-O-HES), which were infused into rabbits, were compared. As a result, 6-O-HES showed a more rapid elimination from the body than 2-O-HES did, thus indicating that 6-O-HES was subjected to the same metabolic changes as 2-O-HES was, which had a lower molar substitution of hydroxyethyl groups by 0.2 to 0.3. This result might be attributed to the substitution-site effect of hydroxyethyl groups on the enzymic degradation of hydroxyethyl starch by α-amylase. Untersuchung von Hydroxyethylstärke. Teil 3. Vergleich des Stoff wechselschicksals von 2-0-Hydroxyethylstärke und 6-0-Hydroxyethylstärke in Kaninchen. Die Blutkonzentration die Nierenausscheidung und die Molekulargrößenverteilung von 6-O-Hydroxyethylstärke (6-O-HES) und 2-O-Hydroxyethylstärke (2-O-HES) wurden nach Infusion in Ratten miteinander verglichen. 6-O-HES wurde schneller aus dem Körper entfernt als 2-O-HES, woraus zu ersehen war, daß 6-O-HES den gleichen stoffwechselbedingten Veränderungen unterlag wie 2-O-HES, welches eine niedrigere molekulare Substitution von 0,2 - 0,3 hatte. Dieses Ergebnis kann der Wirkung der Substitutionsstelle der Hydroxyethylgruppen auf den enzymatischen Abbau von Hydroxyethylstärke durch α-Amylase zugeschrieben werden." @default.
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- W1982120847 date "1984-01-01" @default.
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- W1982120847 title "A Study of Hydroxyethyl Starch. Part III. Comparison of Metabolic Fates between 2-0-Hydroxyethyl Starch and 6-0-Hydroxyethyl Starch in Rabbits" @default.
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- W1982120847 doi "https://doi.org/10.1002/star.19840360606" @default.
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