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• W1982129404 endingPage "1179" @default.
• W1982129404 startingPage "1175" @default.
• W1982129404 abstract "A murine hybridoma has been obtained that produces a monoclonal antibody against the human transferrin receptor. In contrast to previously characterized monoclonal antibodies that recognize the transferrin receptor, this antibody, designated 42/6, blocks the binding of transferrin to its receptor and inhibits the growth of the human T leukemic cell line, CCRF-CEM, in vitro. Inhibition of cell growth was dose dependent, and as little as 2.5 micrograms of purified antibody per ml had a detectable effect, even though transferrin was present in the tissue culture medium in large molar excess. Cells grown in the presence of antibody for 7 days accumulated in S phase of the cell cycle. The addition of iron to antibody-treated cultures in the form of ferric complexes or ferrous sulfate did not overcome the growth inhibitory effects of the anti-transferrin-receptor antibodies. This result suggests that either transferrin is the only means by which CCRF-CEM leukemic cells can be provided with sufficient iron in vitro or that other factors in addition to iron starvation are involved in the antibody-mediated growth inhibition. The inhibition of cell growth by 42/6 monoclonal antibody suggests that monoclonal antibodies against proliferation-associated cell surface antigens, such as the transferrin receptor, may be useful pharmacological reagents to modify cell growth in vitro." @default.
• W1982129404 created "2016-06-24" @default.
• W1982129404 creator A5009607649 @default.
• W1982129404 creator A5032188621 @default.
• W1982129404 date "1982-02-01" @default.
• W1982129404 modified "2023-10-16" @default.
• W1982129404 title "Monoclonal antibody to transferrin receptor blocks transferrin binding and inhibits human tumor cell growth in vitro." @default.
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• W1982129404 doi "https://doi.org/10.1073/pnas.79.4.1175" @default.
• W1982129404 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/345924" @default.
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