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• W1982132053 abstract "Insulin resistance of skeletal muscle, resulting in impaired glucose transport, is a common feature in patients with Type 2 diabetes (T2D) and in their healthy first-degree relatives. In addition to insulin, muscle contraction and hypoxia are the major stimuli to glucose transport in the skeletal muscle. PURPOSE: To determine the effects of acute and chronic intermittent exposure to normobaric hypoxia on the blood glucose concentration and on the insulin sensitivity in oral glucose tolerance test (OGTT). METHODS: In the acute cross-over overnight hypoxia study, patients with T2D (n=11), relatives of T2D (REL, n=14) and endurance athletes (ATH, n=8) were randomized (single-blind) either to hypoxic (FIO2=0.153 ∼ 2500 m) or normoxic 12-h exposure for the first night, and to opposite 12-h exposure for the second night. In the morning, arterial oxygen saturation (SpO2%) was measured, and subjects moved into a normoxic room for a 30-min rest, after which an OGTT was performed. In the chronic intermittent hypoxia study, ATH (n=12) slept and stayed 12-h daily for two weeks in hypoxic rooms, accomplishing daily activities and regular training in ambient normoxia at sea level. Plasma glucose (PG) and serum insulin were determined in OGTT, area under the curve (AUC) for glucose concentration was calculated, and insulin sensitivity (ISIest) was estimated from demographic parameters and values obtained from OGTT. RESULTS: Acute overnight hypoxia: SpO2% reduced in all groups (mean±SD; T2D: 97±3 vs. 91±3, REL: 98±4 vs. 94±7, ATH: 97±3 vs. 91±6; all p<0.001). In T2D and in ATH, hypoxia did not influence fasting PG or insulin concentrations, or their responses in OGTT, but ISIest improved in ATH (0.18±0.14 vs. 0.22±0.14, p<0.01). In REL, PG decreased both in the fasting state (4.60±0.24 vs. 4.41±0.34, p<0.05) and at 120-min (5.34±0.97 vs. 4.83±1.03, p<0.05), AUC decreased (864±107 vs. 813±112, p<0.01) and ISIest improved (0.16±0.04 vs. 0.19±0.07, p<0.01). Chronic two weeks hypoxia: AUC decreased (702±73 vs. 654±67, p=0.06) and ISIest improved with 20% (0.18±0.04 vs. 0.22±0.04, p<0.01). CONCLUSION: Hypoxia improves insulin sensitivity and stimulates glucose disposal in relatives of T2D and in athletes, independent of exercise, but not in patients with T2D." @default.
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• W1982132053 date "2009-05-01" @default.
• W1982132053 modified "2023-10-17" @default.
• W1982132053 title "Overnight Hypoxia Attenuates Glucose Response In Glucose Tolerance Test In Relatives Of Type 2 Diabetics" @default.
• W1982132053 doi "https://doi.org/10.1249/01.mss.0000355282.48116.2e" @default.
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