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• W1982132327 abstract "Abstract Animal studies have shown that in vivo estimates of microvessel density in the brain may be obtained from an MRI‐measurable index ( Q ) provided that a sufficiently high dose of an intravascular paramagnetic contrast agent is employed. Q is determined from the shifts in the transverse relaxation rates induced by the contrast agent, and a high dose is required for the validity of analytic expressions relating Q to the microvessel density. However, the steady‐state imaging techniques used in these prior investigations are not appropriate for humans, as the required contrast agent dose is too large. Here results of a pilot study with three subjects are reported. The results suggest that reliable Q measurements can be performed in the human brain at 1.5 T by using an interleaved spin‐echo (SE)/gradient‐echo (GE) echo‐planar imaging (EPI) sequence and a bolus injection of a triple dose of Gd‐DTPA. Lower‐ and upper‐bound estimates for the microvessel density were derived from the Q ‐values, and were found to be in reasonable accord with previously cited values determined by histology. Magn Reson Med, 2006. © 2006 Wiley‐Liss, Inc." @default.
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• W1982132327 date "2006-10-06" @default.
• W1982132327 modified "2023-10-13" @default.
• W1982132327 title "Microvessel density estimation in the human brain by means of dynamic contrast-enhanced echo-planar imaging" @default.
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• W1982132327 doi "https://doi.org/10.1002/mrm.21052" @default.
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