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- W1982132411 endingPage "2842" @default.
- W1982132411 startingPage "2832" @default.
- W1982132411 abstract "FGFs, in a complex with their receptors (FGFRs) and heparan sulfate (HS), are responsible for a range of cellular functions, from embryogenesis to metabolism. Both germ line and somatic FGFR mutations are known to play a role in a range of diseases, most notably craniosynestosis dysplasias, dwarfism and cancer. Because of the ability of FGFR signalling to induce cell proliferation, migration and survival, FGFRs are readily co-opted by cancer cells. Mutations in, and amplifications of, these receptors are found in a range of cancers with some of the most striking clinical findings relating to their contribution to pathogenesis and progression of female cancers. Here, we outline the molecular mechanisms of FGFR signalling and discuss the role of this pathway in women's cancers, focusing on breast, endometrial, ovarian and cervical carcinomas, and their associated preclinical and clinical data. We also address the rationale for therapeutic intervention and the need for FGFR-targeted therapy to selectively target cancer cells in view of the fundamental roles of FGF signalling in normal physiology." @default.
- W1982132411 created "2016-06-24" @default.
- W1982132411 creator A5047857642 @default.
- W1982132411 creator A5065833377 @default.
- W1982132411 creator A5071002631 @default.
- W1982132411 date "2013-12-01" @default.
- W1982132411 modified "2023-10-18" @default.
- W1982132411 title "FGFR signalling in women's cancers" @default.
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