FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1982132991> ?p ?o ?g. }

• W1982132991 abstract "We have reported previously the localization of the 49 amino acid peptide pancreastatin to all identifiable endocrine cells of porcine gut, pancreas and adrenal, thyroid and pituitary glands. In this study, we have investigated the occurrence of pancreastatin in a series of human neuroendocrine tumours using an antibody to whole synthetic porcine pancreastatin. The most consistent immunostaining for pancreastatin was found in carcinoid tumours of ileum (four out of six), rectum (four out of six), ovary (two out of two) and lung (nine out of 10). Radioimmunoassay of tumour extracts showed that the concentrations of pancreastatin in ileal carcinoids were very high (mean 71.6, range 31.0-184.0 pmol g-1). The high rate of positivity in lung carcinoids contrasted sharply with the results of 10 pulmonary small cell carcinomas which displayed no immunoreactivity and contained minimal concentrations of pancreastatin (mean 2.0, range 0-6.0 pmol g-1). Extra-adrenal paragangliomas also contained pancreastatin (seven out of 10), but although radioimmunoassay detected peptide in phaeochromocytomas (mean 29.8, range 8.0-69.0 pmol g-1), immunocytochemistry did not. Porcine pancreastatin shows structural homology with bovine chromogranin A, an observation which has led to suggestions that chromogranin is a precursor for the peptide. More recently, a sequence homologous to porcine pancreastatin has been identified in the human chromogranin A molecule. In this study, immunostaining with an antiserum to human chromogranin gave positive results in most cases of each tumour type except the small cell carcinomas. The lack of consistent relationships between chromogranin and pancreastatin immunoreactivities may reflect the fact that the antiserum to pancreastatin was raised against the porcine peptide. When antibodies to human pancreastatin become available, the peptide may prove to be a more consistent marker for neuroendocrine tumours." @default.
• W1982132991 created "2016-06-24" @default.
• W1982132991 creator A5002313687 @default.
• W1982132991 creator A5004648678 @default.
• W1982132991 creator A5011196462 @default.
• W1982132991 creator A5025236550 @default.
• W1982132991 creator A5030051266 @default.
• W1982132991 creator A5036343699 @default.
• W1982132991 creator A5066349102 @default.
• W1982132991 creator A5076273573 @default.
• W1982132991 creator A5080564061 @default.
• W1982132991 creator A5090585484 @default.
• W1982132991 date "1988-09-01" @default.
• W1982132991 modified "2023-09-27" @default.
• W1982132991 title "The occurrence of pancreastatin in tumours of the diffuse neuroendocrine system" @default.
• W1982132991 cites W1485133432 @default.
• W1982132991 cites W1569722645 @default.
• W1982132991 cites W1971020206 @default.
• W1982132991 cites W1978162138 @default.
• W1982132991 cites W1998819391 @default.
• W1982132991 cites W2003539081 @default.
• W1982132991 cites W2004764616 @default.
• W1982132991 cites W2013317333 @default.
• W1982132991 cites W2021636820 @default.
• W1982132991 cites W2033785962 @default.
• W1982132991 cites W2044034887 @default.
• W1982132991 cites W2046349824 @default.
• W1982132991 cites W2050485841 @default.
• W1982132991 cites W2053533055 @default.
• W1982132991 cites W2066404205 @default.
• W1982132991 cites W2068850000 @default.
• W1982132991 cites W2086708288 @default.
• W1982132991 cites W2093609695 @default.
• W1982132991 cites W2094024121 @default.
• W1982132991 cites W2095142337 @default.
• W1982132991 cites W2159988573 @default.
• W1982132991 cites W2319457872 @default.
• W1982132991 doi "https://doi.org/10.1016/0890-8508(88)90006-0" @default.
• W1982132991 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2851738" @default.
• W1982132991 hasPublicationYear "1988" @default.
• W1982132991 type Work @default.
• W1982132991 sameAs 1982132991 @default.
• W1982132991 citedByCount "23" @default.
• W1982132991 countsByYear W19821329912015 @default.
• W1982132991 countsByYear W19821329912018 @default.
• W1982132991 crossrefType "journal-article" @default.
• W1982132991 hasAuthorship W1982132991A5002313687 @default.
• W1982132991 hasAuthorship W1982132991A5004648678 @default.
• W1982132991 hasAuthorship W1982132991A5011196462 @default.
• W1982132991 hasAuthorship W1982132991A5025236550 @default.
• W1982132991 hasAuthorship W1982132991A5030051266 @default.
• W1982132991 hasAuthorship W1982132991A5036343699 @default.
• W1982132991 hasAuthorship W1982132991A5066349102 @default.
• W1982132991 hasAuthorship W1982132991A5076273573 @default.
• W1982132991 hasAuthorship W1982132991A5080564061 @default.
• W1982132991 hasAuthorship W1982132991A5090585484 @default.
• W1982132991 hasConcept C103395026 @default.
• W1982132991 hasConcept C126322002 @default.
• W1982132991 hasConcept C134018914 @default.
• W1982132991 hasConcept C142724271 @default.
• W1982132991 hasConcept C176685330 @default.
• W1982132991 hasConcept C203014093 @default.
• W1982132991 hasConcept C204232928 @default.
• W1982132991 hasConcept C2908862229 @default.
• W1982132991 hasConcept C4224716 @default.
• W1982132991 hasConcept C46699223 @default.
• W1982132991 hasConcept C71315377 @default.
• W1982132991 hasConcept C71924100 @default.
• W1982132991 hasConcept C77231918 @default.
• W1982132991 hasConcept C86803240 @default.
• W1982132991 hasConceptScore W1982132991C103395026 @default.
• W1982132991 hasConceptScore W1982132991C126322002 @default.
• W1982132991 hasConceptScore W1982132991C134018914 @default.
• W1982132991 hasConceptScore W1982132991C142724271 @default.
• W1982132991 hasConceptScore W1982132991C176685330 @default.
• W1982132991 hasConceptScore W1982132991C203014093 @default.
• W1982132991 hasConceptScore W1982132991C204232928 @default.
• W1982132991 hasConceptScore W1982132991C2908862229 @default.
• W1982132991 hasConceptScore W1982132991C4224716 @default.
• W1982132991 hasConceptScore W1982132991C46699223 @default.
• W1982132991 hasConceptScore W1982132991C71315377 @default.
• W1982132991 hasConceptScore W1982132991C71924100 @default.
• W1982132991 hasConceptScore W1982132991C77231918 @default.
• W1982132991 hasConceptScore W1982132991C86803240 @default.
• W1982132991 hasLocation W19821329911 @default.
• W1982132991 hasLocation W19821329912 @default.
• W1982132991 hasOpenAccess W1982132991 @default.
• W1982132991 hasPrimaryLocation W19821329911 @default.
• W1982132991 hasRelatedWork W1977596209 @default.
• W1982132991 hasRelatedWork W1982132991 @default.
• W1982132991 hasRelatedWork W2006610112 @default.
• W1982132991 hasRelatedWork W2050301594 @default.
• W1982132991 hasRelatedWork W2051497179 @default.
• W1982132991 hasRelatedWork W2054168415 @default.
• W1982132991 hasRelatedWork W2320205908 @default.
• W1982132991 hasRelatedWork W2403609530 @default.
• W1982132991 hasRelatedWork W3118373417 @default.
• W1982132991 hasRelatedWork W6362310 @default.
• W1982132991 isParatext "false" @default.
• W1982132991 isRetracted "false" @default.

• next